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https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/transdermal-insulin-delivery/
Passive delivery usually occurs with a patch, cream, or spray. Passive Transdermal delivery only works with small molecule drugs, such as nicotine and aspirin. Insulin is far too large to get through the skin passively. Active transdermal delivery, on the other hand, involves a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152630/
Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes. However, skin’s barrier properties prevent insulin permeation at useful levels.We investigated whether microdermabrasion ...Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556146/
Jan 15, 2019 · Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection.Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://www.sciencedirect.com/science/article/pii/S0169409X18303090
Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection.Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
In general, it seems that a transdermal delivery system for insulin is an attractive option. Even though progress in the transdermal delivery of insulin seems promising, because of the poor permeation capacity of insulin and the high susceptibility of the skin to adverse immunological reactions, it is still doubtful whether this delivery route ...
https://professional.diabetes.org/abstract/transdermal-delivery-insulin-patients-type-1-diabetes
Transdermal Delivery of Insulin in Patients with Type 1 Diabetes A novel daily transdermal insu A novel daily transdermal insulin patch is being developed to provide basal levels of insulin in patients with type 1 or type 2 diabetes.
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