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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050019/
The use of low-frequency ultrasound for the transdermal delivery of drugs, referred to as low-frequency sonophoresis (LFS), has been shown to increase skin permeability to a wide range of therapeutic compounds, including both hydrophilic molecules and macromolecules.Author: Baris E Polat, Daniel Blankschtein, Robert Langer
https://link.springer.com/article/10.1023%2FA%3A1016096626810
Mar 01, 1996 · Abstract. Purpose. Application of therapeutic ultrasound (frequency: 1–3 MHz and intensity: 0–2 W/cm 2) enhances transdermal drug transport, although typically by a factor of less than 10. In this paper, we show that application of ultrasound at 20 KHz induces transdermal transport enhancements of up to 1000 times higher than those induced by...Author: Samir S. Mitragotri, Daniel Blankschtein, Robert S. Langer
https://link.springer.com/chapter/10.1007/978-0-387-25844-7_13
Transdermal drug delivery offers several advantages over traditional drug delivery systems such as oral delivery and injection, especially in regard to protein delivery. Transdermal Drug Delivery using Low-Frequency Sonophoresis SpringerLinkAuthor: Samir S. Mitragotri, Daniel Blankschtein, Robert S. Langer
https://www.researchgate.net/publication/226214073_Transdermal_Drug_Delivery_using_Low-Frequency_Sonophoresis
Recent advances in transdermal drug delivery utilizing low-frequency sonophoresis (LFS) and sodium lauryl sulfate (SLS) have revealed that skin permeability enhancement is not …Author: Samir Mitragotri
https://www.sciencedirect.com/science/article/pii/S2251729414000111
Recently, low-frequency ultrasound has been demonstrated to enhance the transdermal delivery of macromolecules and hydrophilic drugs (low-frequency sonophoresis, LFS). As a biological macromolecule, basic fibroblast growth factor (bFGF) also has …Author: Zhihui Zhou, Weiwei Fan, Miaojie Lang, Yanliang Wang
https://www.sciencedirect.com/science/article/pii/S0169409X03002400
However, transdermal transport enhancement induced by low-frequency ultrasound (f<100 kHz) has been found to be more significant than that induced by high frequency ultrasound [23], [34], [54]. Accordingly, this review is focused on low-frequency sonophoresis (20 kHz<f<100 kHz).Author: Samir Mitragotri, Joseph Kost
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