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https://link.springer.com/protocol/10.1007/978-1-59745-210-6_5
Human skin serves a protective function by imposing physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have a suitable lipophilicity and a molecular weight < 500 Da.Author: Marc B. Brown, Matthew J. Traynor, Gary P. Martin, Franklin K. Akomeah
https://www.researchgate.net/publication/5482538_Transdermal_Drug_Delivery_Systems_Skin_Perturbation_Devices
The delivery of drugs of differing lipophilicity and molecular weight, including proteins, peptides and oligonucletides, has been shown to be improved by active methods such as iontophoresis, electroporation, mechanical perturbation and other energy-related techniques such as ultrasound...
https://uhra.herts.ac.uk/handle/2299/3645
For a drug to be delivered passively via the skin it needs to have a suitable lipophilicity and a molecular weight <500 Da. The number of commercially available products based on transdermal or dermal delivery has been limited by these requirements. In recent years various passive and active strategies have emerged to optimize delivery.Author: M.B. Brown, M.J. Traynor, G.P. Martin, F.K. Akomeah
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.567.2826
Abstract. Human skin serves a protective function by imposing physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have a suitable lipophilicity and a molecular weight <500 Da. The number of commercially available products based on transdermal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794664/
Oct 14, 2019 · Metals have strong mechanical strength and toughness for the transdermal drug delivery system. 53 However, metals are nonbiodegradable, which may produce unwanted biohazardous tip waste induced by the broken MNs left behind in the skin, even though some metals, such as SS and Ti, have been safely used as biomaterials in medical treatment for decades. 121,122
https://www.sciencedirect.com/science/article/pii/S0169409X17301801
The external energy stimulates and controls state-of-the-art transdermal delivery systems. Device-assisted transdermal delivery, an ensemble of soft bioelectronics and a transdermal drug delivery system, simultaneously controls the release of drugs and monitors the alteration of the physiological states by the drug (Fig. 2e). The cycle of diagnosis, actuated drug release, and follow-up diagnosis …Author: Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Today, there are 19 transdermal delivery systems for such drugs as estradiol, fentanyl, lidocaine and testosterone; combination patches containing more than one drug for contraception and hormone replacement; and iontophoretic and ultrasonic delivery systems for analgesia (Table 1, Fig. 1). Between 1979 and 2002, a new patch was approved on average every 2.2 years.Author: Mark R Prausnitz, Robert Langer
http://ijpsr.com/bft-article/transdermal-drug-delivery-system-a-review/?view=fulltext
1 Transdermal Drug Delivery System (TDDS) are defined as self contained, discrete dosage forms which are also known as “patches” 2, 3 when patches are applied to the intact skin, deliver the drug through the skin at a controlled rate to the systemic circulation.
https://www.researchgate.net/publication/276837593_The_Structure_of_Skin_and_Transdermal_Drug_Delivery_System-A_Review
The major challenge in designing transdermal drug delivery systems is to overcome the natural transport barrier of the skin. One approach is the use of vesicle formulations.
https://www.pharmacytimes.com/publications/issue/2013/may2013/transdermal-drug-delivery-systems-the-skinny-on-cutaneous-reactions
Transdermal Drug Delivery Systems: The Skinny on Cutaneous Reactions. TDSs have grown in popularity, but side effects that include dermatitis and contact allergic reactions are possible.
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