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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725305/
Ultrasound contrast agents for increased transdermal drug delivery Another interesting approach involves the use of HFS and ultrasound contrast agents (UCAs) in the coupling solution. UCAs are commonly used in contrast-enhanced US imaging of blood perfusion in organs, to measure the blood flow rate in the heart among many other applications [ 58 ].Author: Matthias A Oberli, Carl M Schoellhammer, Robert Langer, Daniel Blankschtein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436072/
Jun 30, 2011 · The use of ultrasound for the transdermal delivery of drugs has been investigated extensively. Mechanisms of skin permeabilization induced by low-frequency ultrasound (low-frequency sonophoresis, LFS) and by therapeutic and high-frequency ultrasound (high-frequency sonophoresis, HFS) are different.Author: Baris E. Polat, Douglas Hart, Robert Langer, Daniel Blankschtein
https://www.sciencedirect.com/science/article/pii/S1359644604031708
Use of ultrasound for transdermal drug delivery In the past two decades, with the development of transdermal delivery as an important means of systemic drug administration, researchers have been investigating the possible application of ultrasound for transdermal delivery systems.Author: Ilana Lavon, Joseph Kost
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676802/
Ultrasound enhanced transdermal drug delivery offers advantages over traditional injection drug delivery methods which are invasive and painful. Currently few drugs, proteins or peptides have been successfully administered transdermally for clinical applications because of the low skin permeability to these relatively large molecules.Author: Nadine Barrie Smith
https://www.sciencedirect.com/science/article/pii/S0169409X14000088
Ultrasound has been used extensively to enhance transdermal drug delivery, and has also been used on skin for other applications. For example, Voigt et al. [51] used ultrasound (20–30 kHz) as adjunctive treatment to improve the healing of chronic wounds.Author: Aharon Azagury, Luai Khoury, Giora Enden, Joseph Kost
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635663/
Apr 22, 2013 · Transdermal drug delivery. Use of ultrasound to deliver drugs more efficiently through the skin is referred to as sonophoresis.55 In earlier studies, the ultrasound used most often was high-frequency sonophoresis (frequencies ≥ 0.7 MHz).Author: Ying-Zheng Zhao, Li-Na Du, Cui-Tao Lu, Yi-Guang Jin, Shu-Ping Ge
https://www.nature.com/articles/s41598-020-58822-w
Feb 06, 2020 · Effect of ultrasonic stimulation on HA microneedle dissolution. In the case of using ultrasound for transdermal delivery, the mechanism shown in …Author: Moonjeong Bok, Zhi-Jun Zhao, Sohee Jeon, Jun-Ho Jeong, Eunju Lim
https://www.ncbi.nlm.nih.gov/pubmed/18997767
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality.Author: Mark R Prausnitz, Robert Langer
https://www.researchgate.net/publication/305317105_A_Review_on_Ultrasound_Parameters_and_Methods_of_Application_in_Transdermal_Drug_Delivery
The transdermal route of drug delivery has attracted medical and pharmacological researchers due to its advantages over other methods of drug delivery. ... The use of ultrasound for the delivery ...
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