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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://www.frontiersin.org/articles/10.3389/fbioe.2018.00015/full
The move from passive transdermal drug delivery concepts to controllable and on-demand delivery platforms will allow the realization of real personalized point-of-care medication. The clinical potential of light-based transdermal activation using lasers, photodiodes and in combination with light-to-heat converting materials is large.Author: Sabine Szunerits, Rabah Boukherroub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5].The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://academic.oup.com/bjaed/article/7/5/171/535087
Oct 01, 2007 · Molecular weight 286 468 337 ... In both groups, patient satisfaction is greater with preference for transdermal drug delivery as this is associated with less side-effects (e.g. constipation) and is more convenient. Improvements in measures of quality of life have also been reported in cancer pain patients receiving opioid TDDS.Author: Lyn Margetts, Richard Sawyer
https://clinicalgate.com/topical-and-transdermal-drug-delivery/
Aug 02, 2015 · • Drugs suitable for transdermal and topical drug delivery usually have a molecular weight <500 Da, a between 1 and 4, and an effective daily dose of < 10 mg/day. • Permeant transport through skin is largely by passive diffusion and can be modelled by Fickian diffusion laws.
https://www.researchgate.net/publication/308802974_Formulation_Considerations_And_Factors_Affecting_Transdermal_Drug_Delivery_System-A_Review
However, according to Maryam et al., [20], the preferred molecular weight for the transdermal drug delivery system of the drug by passive diffusion is less than 500 Dalton. ...
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