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https://www.frontiersin.org/articles/10.3389/fbioe.2018.00015/full
The move from passive transdermal drug delivery concepts to controllable and on-demand delivery platforms will allow the realization of real personalized point-of-care medication. The clinical potential of light-based transdermal activation using lasers, photodiodes and in combination with light-to-heat converting materials is large.Author: Sabine Szunerits, Rabah Boukherroub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175749/
Skin permeability and local blood perfusion are important factors for transdermal drug delivery. Application of heat is expected to enhance microcirculation and local perfusion and/or blood vessel permeability, thus facilitating drug transfer to the systemic circulation.Author: Kristian Kjær Petersen, Mark Lillelund Rousing, Carina Jensen, Lars Arendt-Nielsen, Parisa Gazerani
http://www.jarcet.com/articles/Vol2Iss1/Hull.htm
Heat-Enhanced Transdermal Drug Delivery: A Survey Paper* Wade Hull, MS. Director of Engineering. ZARS, Inc. 350 W. 800 N., Ste. 320. Salt Lake City, Utah 84103
https://www.fda.gov/industry/generic-drug-user-fee-amendments/fys-2013-2017-gdufa-science-and-research-report-transdermal-drug-products
Influence of heat on reference and generic transdermal drug delivery systems. The American Association of Pharmaceutical Scientists Annual Meeting, November 2014, San Diego, CA.
http://grantome.com/grant/NIH/U01-FD004955-04
Drug release from different transdermal drug delivery systems (TDDS) is governed by a number of factors including: skin condition, occlusion, exposure to heat, different inactive ingredients, sweat, age and patch design (reservoir vs. matrix).
http://ijpsr.com/bft-article/transdermal-drug-delivery-system-a-review/?view=fulltext
ABSTRACT: A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch ...
https://academic.oup.com/painmedicine/article/1/3/225/1861569
Oct 09, 2008 · One possible explanation is that the use of heat drives the drug from the patch, through the subcutaneous skin depot known to be present in transdermal drug delivery, into the systemic circulation, and rapidly enough that the skin depot does not become saturated.Author: JD T. Samuel Shomaker Md, Jie Zhang, Mph Michael A. Ashburn Md
https://www.researchgate.net/publication/261759007_TRANSDERMAL_DRUG_DELIVERY_SYSTEM_A_REVIEW
Transdermal drug delivery has made an important contribution to medical practice, but it has yet to fully achieve its potential as an alternative to the oral delivery and hypodermic injections.
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