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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://www.researchgate.net/publication/12600465_Transdermal_Delivery_of_Macromolecules_Using_Skin_Electroporation
(1) To evaluate the feasibility of transdermal delivery of macromolecules by skin electroporation. (2) To assess the influence of the molecular weight of the permeant on transport and examine ...
https://pubs.acs.org/doi/abs/10.1021/bm301293d
Nov 02, 2012 · This paper introduces a chitosan microneedle patch for efficient and sustained transdermal delivery of hydrophilic macromolecules. Chitosan microneedles have sufficient mechanical strength to be inserted in vitro into porcine skin at approximately 250 μm in depth and in vivo into rat skin at approximately 200 μm in depth.Author: Mei Chin Chen, Ming Hung Ling, Kuan Ying Lai, Esar Pramudityo
http://drugdelivery.chbe.gatech.edu/Papers/1997/Prausnitz%20Trans%20Del%20of%20Macro%20Prot%20Pep%20Form%201997.pdf
Transdermal Delivery of Macromolecules: Recent Advances by Modification of Skin's Barrier Properties Mark R. Prausnitz School of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100 Great advances in transderrnal delivery of macromolecules have been made within the last few years using ultradeforrnable liposomes,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050019/
Importance of the field. Transdermal delivery of macromolecules provides an attractive alternative route of drug administration when compared to oral delivery and hypodermic injection, because of its ability to bypass the harsh gastro-intestinal tract and deliver therapeutics non-invasively.Author: Baris E Polat, Daniel Blankschtein, Robert Langer
https://www.pnas.org/content/pnas/100/24/13755.full.pdf
Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies Devin V. McAllister*, Ping M. Wang*, Shawn P. Davis*, Jung-Hwan Park*†, Paul J. Canatella*, Mark G. Allen‡, and Mark R. Prausnitz*†§Author: Devin V. McAllister, Ping M. Wang, Shawn P. Davis, Jung-Hwan Park, Paul J. Canatella, Mark G. Allen,...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
Anushree Herwadkar, Ajay K. Banga, in Peptide and Protein Delivery, 2011. Transdermal delivery of peptides and proteins is a promising alternative to conventional parenteral delivery. Enhancement techniques such as microporation, iontophoresis, or sonophoresis help bypass penetration barriers of the skin and enable the delivery of hydrophilic molecules and macromolecules.
https://www.sciencedirect.com/science/article/pii/S0168365919305139
Using fluorescent imaging, we qualitatively compared the influence of CAGE and PBS on transdermal delivery of a variety of macromolecules We saw a significant increase in permeation in presence of CAGE. The primary focus was on the assessment of the dependence of transport on solute MW, which was performed using FITC-dextran.Author: Qin M. Qi, Samir Mitragotri
https://pubs.acs.org/doi/abs/10.1021/bk-1997-0675.ch008
Transdermal drug delivery is a potentially useful method by which macromolecules, such as proteins, could be administered for local or systemic therapy. Until recently, transdermal delivery was not a realistic option, since skin's great barrier properties had prevented transport of macromolecules across human skin at therapeutically-relevant rates.
https://tmu.pure.elsevier.com/en/publications/transdermal-delivery-of-macromolecules-by-erbium-yag-laser
Nov 05, 2004 · The aim of this study was to assess the effect of molecular weight (MW) on the transdermal delivery of macromolecules by erbium:yttrium-aluminum-garnet (Er:YAG) laser treatment.Author: Jia You Fang, Woan Ruoh Lee, Woan Ruoh Lee, Shing Chuan Shen, Hsin Yuan Wang, Chia Lang Fang, Chung-...
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