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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Today, there are 19 transdermal delivery systems for such drugs as estradiol, fentanyl, lidocaine and testosterone; combination patches containing more than one drug for contraception and hormone replacement; and iontophoretic and ultrasonic delivery systems for analgesia (Table 1, Fig. 1). Between 1979 and 2002, a new patch was approved on average every 2.2 years.Author: Mark R Prausnitz, Robert Langer
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
10.6 Advantages of Topical and Transdermal Drug Delivery. Transdermal delivery provides suitable and painless self-administration for patients. It overcomes frequent dosing administration, plasma level instability related to oral dosing and injections to uphold constant drug concentrations, and a drug with a short half-life can be supplied effortlessly.
https://www.sciencedirect.com/topics/nursing-and-health-professions/transdermal-drug-delivery-system
Transdermal drug delivery systems provide an easy, reliable mechanism of administering drugs when rapid onset is not important. Transdermal drug delivery bypasses the enterohepatic circulation, thereby providing a more reliable clinical action.
https://clinicalgate.com/topical-and-transdermal-drug-delivery/
Aug 02, 2015 · • Drugs suitable for transdermal and topical drug delivery usually have a molecular weight <500 Da, a between 1 and 4, and an effective daily dose of < 10 mg/day. • Permeant transport through skin is largely by passive diffusion and can be modelled by Fickian diffusion laws.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5]. The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://academic.oup.com/bjaed/article/7/5/171/535087
Oct 01, 2007 · Transdermal delivery systems. There are two designs of transdermal patch currently available: the reservoir, or membrane-controlled system, and the matrix system. A reservoir patch holds the drug in a gel or solution and delivery is determined by a rate-controlling membrane between the drug reservoir and the skin (Fig.Author: Lyn Margetts, Richard Sawyer
https://www.pharmacytimes.com/publications/issue/2016/august2016/delivery-methods-the-patch-versus-the-oral-route
Transdermal administration delivers medication through the skin via patches or other delivery systems. 1-4 Although comparable to oral-dosage forms in efficacy, transdermal patches have numerous advantages over oral forms. First, transdermal administration avoids the first-pass effect of metabolism associated with the oral route.
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