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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · Microneedles can be used to enhance transdermal drug delivery. In this review, different types of microneedles are described and their methods of fabrication highlighted. Microneedles can be fabricated in different forms: hollow, solid, and dissolving.Author: Kevin B. Ita
https://www.dermarollershop.com/blog/microneedles-transdermal-drug-delivery-dynamic-duo/
One of the major uses of microneedles is transdermal drug delivery. But the success of this route has severely limited by the inability of some medications to enter the skin at a therapeutically useful rate. Just recently, there is an increasing use of micron-scale needles in increasing the skin permeability. It has been shown that […]
https://pubs.rsc.org/en/Content/ArticleLanding/2020/RA/D0RA00735H
The skin is an absorptive organ, targeted in the transdermal delivery system. The microneedle method is an updated approach to deliver compounds through the skin in an efficient way. A microneedle patch is composed of dozens to hundreds of micron-sized needles …
https://www.ondrugdelivery.com/wp-content/uploads/2017/05/1060_GF_ONdrgDelivery_Issue-56_-transdermal_MR.pdf
transdermal delivery using natural moisturising factor components highly customisable hollow polymer microneedle solutions successful mass production of dissolvable p08 p14 p19 microneedle technology transdermal delivery & microneedles march 31st, 2015 • issue n o 56
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Microneedle application is an emerging technique for transdermal drug delivery and this is reflected by the large number of patent applications filed. 125-133 The majority of these patent applications are focused around design of, and delivery through, hollow microneedles since a higher amount of drug can be delivered from such microneedles as compared with other microneedles. Many of the patents based on hollow microneedle …Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
(a) Solid microneedles (150 μm tall) etched from a silicon wafer were used in the first study to demonstrate microneedles for transdermal delivery. (b) Solid microneedles (1000 μm tall) laser-cut from a stainless steel sheet were used to deliver insulin to diabetic rats.Author: Mark R Prausnitz
http://multimedia.3m.com/mws/media/1080389O/ondrugdelivery-article-march-2015.pdf
With 3M Hollow Microstructured Transdermal System, it is possible to deliver more viscous solutions, up to 25 centipoise (cp), with options for delivery of up to 80 cp. The drug product formulation must also be chemically compatible with the device. This is essential, especially upon stability storage.
https://www.ncbi.nlm.nih.gov/pubmed/18997767
Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase its impact on medicine.Author: Mark R Prausnitz, Robert Langer
https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/microneedle/
Differentiate your product with an innovative hollow microneedle technology based on the latest human factors testing and voice-of-customer research. The 3M Hollow Microstructured Transdermal System delivers liquid formulations of 0.5 mL to 2 mL over a range of viscosities. A clinical device …
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