We have collected information about Transcutaneous Drug Delivery for you. Follow the links to find out details on Transcutaneous Drug Delivery.
https://medical-dictionary.thefreedictionary.com/transcutaneous+drug+delivery
Transdermal therapy Therapeutics Use of topical prolonged-release forms of drugs; transcutaneous penetration of a drug requires that it traverse the intercellular lipid layer surrounding the cells of the stratum corneum–rather than through the cells themselves, but also the aqueous environment of the basal cells of the epidermis and the dermis Most ...
https://www.sciencedirect.com/science/article/pii/S0025619611643188
Thus, transcutaneous drug delivery may be best for a potent drug with a wide therapeutic window in which firstpass hepatic biotransformation must be avoided. The drug should be potent enough that only small amounts are needed for topical application, and it should have a wide therapeutic range to avoid differences in efficacy and development of toxicity due to variability in absorption. 14Author: Jeffrey J. Berti, James J. Lipsky
https://www.mayoclinicproceedings.org/article/S0025-6196(11)64318-8/fulltext
Mar 03, 2014 · Transcutaneous drug delivery has many theoretic and practical advantages and disadvantages, and such issues are often a concern for both clinicians and patients. This review of this relatively novel method of drug delivery serves as a foundation to address these concerns and provides practical knowledge for clinicians to optimize patient care.Author: Jeffrey J. Berti, James J. Lipsky
https://www.sciencedirect.com/science/article/abs/pii/S0025619611643188
The physiochemical properties of the drug preparation that are factors in the effectiveness of transcutaneous transport are drug stability or volatility, use of a solvent carrier or vehicle, use of a penetration enhancer, and type of delivery device. Because a drug should remain on the skin without evaporating or becoming otherwise inactive, it is suspended in a vehicle-any gel, lotion, or paste used to apply the drug …Author: Jeffrey J. Berti, James J. Lipsky
https://www.ncbi.nlm.nih.gov/pubmed/7776720
The delivery system itself occasionally proves to be the ultimate determinant of transdermal drug flow. RESULTS: The advantages of transcutaneous drug delivery are avoidance of the gastrointestinal tract and hepatic first-pass biotransformation and metabolism, control of absorption, availability of multiple skin sites to avoid local irritation and toxicity, and improved patient compliance.Author: Jeffrey J. Berti, James J. Lipsky
https://www.ncbi.nlm.nih.gov/pubmed/30300013
Discussion: Transcutaneous drug delivery via fractional laser and microneedling is a promising modality with preliminary evidence for increased hair regrowth over topical therapy alone. Further studies are needed to elucidate treatment parameters and appropriate device selection for drug delivery.Author: Angela Wipf, Nicholas Boysen, Maria K. Hordinsky, Emily E. Dando, Neil Sadick, Ronda S. Farah
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