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https://www.liebertpub.com/doi/10.1089/jop.1986.2.67
The focus of this review is on recent developments in topical ocular drug delivery systems relative to their success in overcoming the constraints imposed by the eye and to the improvements that have yet to be made. In addition, this review attempts to place in perspective the importance of …Author: Vincent H.L. Lee, Joseph R. Robinson
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bd69fee03-15c5-4fbd-a090-4f8a5b294c17%7D/understanding-topical-ophthalmic-drug-delivery-how-much-gets-in
The cornea is the primary route of topical ocular drug absorption and offers significant anatomical barriers. There is less than 5 minutes of ocular surface contact time for any drop; for this reason and the above considerations, approximately 5% of the original dose reaches...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473722/
Jun 11, 2015 · To date, means for enhancing topical drug delivery to the front of the eye often rely on viscosity-enhancing agents, which can lead to patient discomfort and lack of compliance, and generally only provide slight improvement in drug retention on the ocular surface.Author: Lisa R. Schopf, Alexey M. Popov, Elizabeth M. Enlow, James L. Bourassa, Winston Z. Ong, Pawel Nowak,...
https://clinicalgate.com/ocular-drug-delivery/
Key points. • Drug delivery routes available for treating ocular conditions are topical, systemic (oral or injection), intraocular or periocular (injection or implant). • Topical ophthalmic preparations can be classified into solutions, suspensions, ointments, gels and sub-micron emulsions.
https://drug-dev.com/eyesol-a-novel-topical-ocular-drug-delivery-system-for-poorly-soluble-drugs/
CHALLENGES OF TOPICAL OCULAR DRUG DELIVERY The very nature of the eye makes any drug treatment particularly challenging. The eye is a very sensitive organ immediately reacting to both mechanical and chemical irritation Therefore, formulation options are limited.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · COLLOIDAL DOSAGE FORMS FOR OCULAR DRUG DELIVERY. Colloidal dosage forms have been widely studied and employed in the field of ocular drug delivery . These dosage forms include liposomes, nanoparticles, microemulsions, and nanoemulsions etc. Barriers to ocular drug delivery have already been described earlier in the context of structure and function of various ocular …Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
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