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https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-3768.2011.02299.x
Jan 23, 2012 · The serum dorzolamide concentrations were relatively low (i.e. 0.3–0.4 μg/ml). Thus, the dorzolamide delivery from the aqueous eye drop microsuspension did target the eye and minimized systemic drug delivery. These results indicate that this dorzolamide eye drop formulation has the potential of being developed into a once‐a‐day product.Author: Thorsteinn Loftsson, Phatsawee Jansook, Einar Stefánsson
https://www.researchgate.net/publication/221769852_Topical_drug_delivery_to_the_eye_Dorzolamide
Our findings suggest that this MUCO_NM preparation is a promising carrier for topical delivery of dorzolamide to the eye, with enhanced drug efficacy and the potential to reduce administration ...
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1755-3768.2011.02299.x
chemical properties of the drug are shown in Table 1. Dorzolamide has two pKa values, i.e. 6.4 and 8.5. It is Review Article Topical drug delivery to the eye: dorzolamide Thorsteinn Loftsson,1 Phatsawee Jansook1 and Einar Stefa´nsson2 1Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland 2Department of Ophthalmology ...Author: Thorsteinn Loftsson, Phatsawee Jansook, Einar Stefánsson
https://www.sciencedirect.com/science/article/pii/S0378517317302910
However, for effective topical drug delivery into the eye a delivery system is needed that addresses all three obstacles, that is increases drug solubility in the aqueous tear film, increases the contact time of the drug with the eye surface and increases drug partition into and then drug permeation through the lipophilic membrane barriers (i.e ...Author: Thorsteinn Loftsson, Einar Stefánsson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802135/
Nanoemulsions as a drug delivery system were utilized in our study for formulating dorzolamide hydrochloride as ocular eye drops in virtue of their distinct advantages (23–25). These include sustained release of the drug applied to the cornea, high penetration in the deeper layers of the ocular structure, and aqueous humor as well as ease of ...Author: Hussein O. Ammar, H. A. Salama, M. Ghorab, A. A. Mahmoud
https://www.sciencedirect.com/science/article/pii/S0378517317301254
However, in an eye drop formulation, dorzolamide is rapidly cleared from the preocular space, hence requiring multiple daily administrations. Here, we sought to increase the preocular retention of dorzolamide using nanostructured, mucoadhesive microparticles (MUCO_NM) as carriers for topical delivery to the eye.Author: Chun Gwon Park, Young Kook Kim, Young Kook Kim, Se Na Kim, Seung Ho Lee, Beom Kang Huh, Min A. Park,...
https://www.academia.edu/12202865/Topical_drug_delivery_to_the_eye_dorzolamide
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232551/
Jul 19, 2018 · Dorzolamide is a topical carbonic anhydrase II and XII inhibitor that can be administered topically, directly into the eye, as a 2% water solution [].Common side effects are conjunctivitis, erythema and eyelid edema [].To the best of our knowledge, true contact dermatitis to Dorzolamide is rare and only a few cases have been reported in the literature [].Author: Diego Orsini, Andrea D'Arino, Flavia Pigliacelli, Chiara Assorgi, Alessandra Latini, Antonio Cristau...
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