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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425738/
Apr 10, 2014 · For gene suppression in skin, topical delivery of siRNA offers several benefits including direct access to the target site, reduced adverse effects typically associated with systemic administration, possibility of visual monitoring of the affected region and the possibility of surgical removal of aberrant tissue if unwanted side effects occur ...Author: Ming Chen, Michael Zakrewsky, Vivek Gupta, Aaron C. Anselmo, Deborah H. Slee, John A. Muraski, Samir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409786/
Jul 24, 2012 · Topical delivery of 1.5 uM EGFR siRNA (50 nM SNA-NCs) for 3 wk to hairless mouse skin almost completely abolishes EGFR expression, suppresses downstream ERK phosphorylation, and reduces epidermal thickness by almost 40%. Similarly, EGFR mRNA in human skin equivalents is reduced by 52% after 60 h of treatment with 25 nM EGFR SNA-NCs.Author: Dan Zheng, Dan Zheng, David A. Giljohann, David A. Giljohann, David L. Chen, Matthew D. Massich, Mat...
https://www.researchgate.net/publication/281713077_Progress_in_Topical_siRNA_Delivery_Approaches_for_Skin_Disorders
The topical delivery of siRNA based therapies has opened new perspectives for the treatment of skin disorders. The use of siRNA is limited due to the rapid degradation and poor cellular uptake.
https://www.sciencedirect.com/science/article/pii/S0168365914000236
The nanoparticle systems have shown possibility and efficacy as topical delivery systems for siRNA , , . On the other hand, skin penetrating peptides provide a …Author: Ming Chen, Michael Zakrewsky, Vivek Gupta, Aaron C. Anselmo, Deborah H. Slee, John A. Muraski, Samir...
http://www.biopharminternational.com/discovery-pipeline-topical-delivery-sirna
Jul 06, 2012 · A team from Northwestern University has demonstrated the feasibility of topical delivery of small interfering RNA (siRNA) in a July 2012 publication online in the Proceedings of the National Academy of Sciences.To date, the biggest hurdle in developing (siRNA) therapeutics to effect gene knockdown in vivo has been designing an effective delivery system.
https://www.nature.com/articles/srep26278
May 18, 2016 · Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8. ... Chen, M. et al. Topical delivery of siRNA into skin using SPACE-peptide carriers. J …Author: Ankur Gautam, Jagpreet Singh Nanda, Jesse S. Samuel, Manisha Kumari, Priyanka Priyanka, Gursimran Be...
https://www.sciencedirect.com/science/article/pii/S016836591300240X
Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo. ... The ideal siRNA delivery system for the skin should have several characteristics: one to help siRNA to transverse the SC, second to protect siRNA during penetration process and third to facilitate ...Author: Pinaki R. Desai, Srujan Marepally, Srujan Marepally, Apurva R. Patel, Chandrashekhar Voshavar, Chand...
https://www.pnas.org/content/pnas/109/30/11975.full.pdf
knockdown. Therefore, we hypothesized that siRNA-based SNA gold nanoparticle conjugates might be ideal topical delivery agents to treat diseases of the skin. Results To evaluate the potential for targeted gene suppression by siRNA-based SNA-NCs through noninvasive topical delivery, we first investigated their uptake in primary normal human ker-Author: Dan Zheng, Dan Zheng, David A. Giljohann, David A. Giljohann, David L. Chen, Matthew D. Massich, Mat...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(19)30207-0.pdf
Due to the short half-life of siRNA molecules, a daily reversible and dosage-variable treatment regimen by non-invasive topical delivery is necessary. However, effective delivery remains a challenge, and presently no published research reports significant siRNA delivery to an intact corneal epithelium.11,28
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30207-0
Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a frequent long-term treatment regimen, whereas topical delivery of siRNA to the cornea is hampered by the eye surface’s protective mechanisms. Herein ...Author: Davide Schiroli, María José Gómara, Eleonora Maurizi, Sarah D. Atkinson, Laura C. Mairs, Kathleen A....
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