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https://www.sciencedirect.com/science/article/pii/S0169409X05001638
It is somewhat dogmatic that topical ocular delivery is insufficient to achieve therapeutic drug levels in the posterior segments. However, some drugs are currently challenging this dogma. In this review we investigate the constraints and challenges of drug delivery to the posterior segment.Author: Patrick M. Hughes, Orest Olejnik, Joan-En Chang-Lin, Clive G. Wilson
https://www.researchgate.net/publication/7479939_Topical_and_systemic_drug_delivery_to_the_posterior_segments
It is somewhat dogmatic that topical ocular delivery is insufficient to achieve therapeutic drug levels in the posterior segments. However, some drugs are currently challenging this dogma.
https://www.sciencedirect.com/science/article/abs/pii/S0169409X05001638
The posterior segments of the eye are exquisitely protected from the external environment. This poses unique and fairly challenging hurdles for drug delivery. It is somewhat dogmatic that topical ocular delivery is insufficient to achieve therapeutic drug levels in the posterior segments. However, some drugs are currently challenging this dogma.Author: Patrick M. Hughes, Orest Olejnik, Joan-En Chang-Lin, Clive G. Wilson
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0420.2007.00885.x
of topical and systemic absorption in drug delivery to the retina and other ocular tissues. This study aimed to answer the fol-lowing questions: (1) What are the relative efficiencies of topical versus systemic absorption of eyedrops in drug delivery to tissues in the anterior and posterior segments of the rabbit eye? (2) Can dexamethasone ...Author: Hakon H. Sigurdsson, Fífa Konráðsdóttir, Thorsteinn Loftsson, Einar Stefánsson
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0420.2007.00885.x
Topical absorption also plays a significant role in delivering dexamethasone to the posterior segment of the rabbit eye. In medication administered to the retina, 40% of the drug reaches the retina via the systemic route and 60% via topical penetration. Dexamethasone‐cyclodextrin eyedrops deliver a significant amount of drug to the rabbit retina.Author: Hakon H. Sigurdsson, Fífa Konráðsdóttir, Thorsteinn Loftsson, Einar Stefánsson
https://www.ncbi.nlm.nih.gov/pubmed/28391041
Oct 15, 2017 · Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye. Loftsson T(1), Stefánsson E(2). Author information: (1)Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland.Author: Thorsteinn Loftsson, Einar Stefánsson
https://link.springer.com/article/10.1007/s11095-018-2519-x
Oct 29, 2018 · Topical instillation of eye drops is non-invasive and the most common route for administering therapeutics to the eye. Although this route is a viable method of drug delivery for the treatment of anterior segment diseases, it remains a major challenge to efficiently deliver drugs topically to treat posterior segment diseases such as age-related macular degeneration (AMD) and diabetic …Author: Gerard A. Rodrigues, David Lutz, Jie Shen, Xiaoda Yuan, Hong Shen, James Cunningham, Hongwen M. Rive...
https://www.researchgate.net/publication/227808169_Topical_and_systemic_absorption_in_delivery_of_dexamethasone_to_the_anterior_and_posterior_segments_of_the_eye
Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye Article in Acta Ophthalmologica Scandinavica 85(6):598 - 602 · September 2007 with ...
https://www.deepdyve.com/lp/elsevier/topical-and-systemic-drug-delivery-to-the-posterior-segments-sD27gUWDxx
Dec 13, 2005 · Read "Topical and systemic drug delivery to the posterior segments, Advanced Drug Delivery Reviews" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://link.springer.com/chapter/10.1007/978-3-319-47691-9_5
Nov 18, 2016 · Ophthalmologists still face challenges in treating different diseases of the anterior and posterior segments. Systemic, intraocular, and other methods of drug delivery are explained below with major emphasis on topical deliveries.Author: Lunawati Bennett
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