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https://www.researchgate.net/publication/7775899_Cell-penetrating_peptides_Tools_for_intracellular_delivery_of_therapeutics
Request PDF Cell-penetrating peptides: Tools for intracellular delivery of therapeutics The main problem of therapeutic efficiency lies in the crossing of cellular membranes.
https://link.springer.com/10.1007/s00018-005-5109-0
Jun 17, 2005 · Here, we give an extensive review of peptide-mediated delivery systems and discuss their applications, with particular focus on the mechanisms leading to cellular internalization. Cell-penetrating peptides: tools for intracellular delivery of therapeutics SpringerLinkAuthor: S. Deshayes, M. C. Morris, G. Divita, F. Heitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755874/
Aug 01, 2012 · Therapeutic Potential of Recombinant Protein Therapeutics for Targeted Intracellular Compartment Delivery in GBM Cells Some isotopes and therapeutics such as photosensitizers have a small radius of action (e.g. photosensitizers, radius of action ~0.01 µm to 0.02 µm due to the short half-life of the activated drug of ~0.4 µs compared with tumor cell size of −10 µm).Author: Hetal Pandya, Waldemar Debinski
https://www.nature.com/articles/ncomms12277
Jul 22, 2016 · Here we describe a new tool for intracellular delivery of target proteins, named ‘exosomes for protein loading via optically reversible protein–protein interactions’ (EXPLORs). By integrating a reversible protein–protein interaction module controlled by blue light with the endogenous process of exosome biogenesis,...Author: Nambin Yim, Seung Wook Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, ...
https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/intracellular-delivery-of-biologic-therapeutics-by-bacterial-secretion-systems/38E0CB06CD4CA6AA6BC70F2EAAE79CB2
Intracellular delivery of biologic therapeutics by bacterial secretion systems - Volume 19 - Barnabas James Walker, Guy-Bart V. Stan, Karen Marie Polizzi Skip to main content Accessibility help We use cookies to distinguish you from other users and to provide you with a better experience on our websites.
https://www.sciencedirect.com/science/article/pii/S0168365915302832
Though therapeutics based on messenger RNA (mRNA) have broad potential in applications such as protein replacement therapy, cancer immunotherapy, and genomic engineering, their effective intracellular delivery remains a challenge.Author: Kevin J. Kauffman, Matthew J. Webber, Matthew J. Webber, Daniel G. Anderson
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Intracellular delivery of therapeutics antibodies by cell-penetrating peptides. In certain cases, the antibodies need to be delivered intracellularly for their tumoricidal effect ; however, immunoglobulins by themselves cannot cross the plasma membrane.Author: Vladimir Torchilin
https://www.researchgate.net/publication/290446720_Nano-Enabled_Delivery_of_Intracellular_Therapeutics
Oct 15, 2015 · Nano-Enabled Delivery of Intracellular Therapeutics 107 2 Crossing the Cell Membrane and Internalization A primary barrier preventing successful cellular delivery is the cellular membrane.
https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.23974
The use of enzymes as therapeutics is very promising because of their catalytic activity and specificity. However, intracellular delivery of active enzymes is challenging due to their low stability a...Author: Lina Herrera Estrada, Stanley Chu, Julie A. Champion
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