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https://www.sciencedirect.com/science/article/pii/S0169409X04000432
Tocol emulsions for drug solubilization and parenteral delivery 1. Introduction. For drugs that cannot be formulated as an aqueous solution,... 2. Tocol emulsions. The utility of vitamin E in emulsions is well known [13], [14]. 3. Tocol emulsions of paclitaxel. Paclitaxel, a naturally derived ...Author: Panayiotis P Constantinides, Alex Tustian, Dean R Kessler
https://www.sciencedirect.com/science/article/abs/pii/S0169409X04000432
The most common tocol is d-α-tocopherol, also known as vitamin E. Tocols can be excellent solvents for water insoluble drugs and are compatible with other cosolvents, oils and surfactants. This review highlights the major developments in the use of tocols in parenteral emulsions for drug delivery, with a focus on drug solubilization, physicochemical properties, and biopharmaceutical applications.Author: Panayiotis P Constantinides, Alex Tustian, Dean R Kessler
https://www.researchgate.net/publication/8594936_Tocol_emulsions_for_drug_solubilization_and_parenteral_delivery
Tocopherol (tocol) nanoemulsions offer a better alternative as compared to triglyceridebased nanoemulsion for parenteral delivery (globule size usually < 300 nm) of hydrophobic drugs with poor solubility in both oil and water [13] such as CUR in addition to that tocol acetate has been...
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/56/issue/9
Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs Anatoly N. Lukyanov, Vladimir P. Torchilin Pages 1273-1289
https://www.sciencedirect.com/science/article/pii/B9780444537980000225
For intravenous administration, however, one limitation with lipid emulsions (for delivery of drugs which are poorly soluble in water) is the need for biocompatibility of the oil phase and surfactants used [807]. A good example of a challenging drug, with the above formulation drawbacks, is paclitaxel (cf.Author: Joseph D'Arrigo
https://www.ncbi.nlm.nih.gov/medgen/473244
Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells.
https://www.sciencedirect.com/science/article/pii/S0378517308000112
A recent advance was the use of tocopherol or derivatives thereof as the oil phase of emulsions (tocol emulsions) for drug solubilization and parenteral delivery (Constantinides et al., 2004). More recently, a tocol emulsion for the intravenous delivery of CLA was prepared and demonstrated a marked pain reduction (Lu et al., 2008). However, the concentration of drug in the formulation was 2.5 …Author: Jie Li, Shufang Nie, Xingang Yang, Changguang Wang, Shuxia Cui, Weisan Pan
https://www.sciencedirect.com/science/article/pii/S0169409X07003183
Mar 17, 2008 · Triglyceride emulsions, liposomes and micellar solutions have been traditionally used to accomplish these tasks and there are several products on the market using these lipid formulations. The broader application of these lipid systems in parenteral drug delivery, however, particularly with new chemical entities,...Author: Panayiotis P. Constantinides, Mahesh V. Chaubal, Robert Shorr
https://www.sciencedirect.com/science/article/pii/S0378517306009744
Apr 20, 2007 · Resveratrol was gradually released from the Brij 35-containing tocol emulsion for 48 h, indicating that this emulsion could be a carrier for controlled resveratrol delivery. The drug is stably retained in the vesicles for a determined duration, followed by a slow release into the external phase.Author: Chi Feng Hung, Chia Lang Fang, Mei Hui Liao, Jia You Fang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011075/
Oct 26, 2010 · This drug delivery approach finds its roots in the now well-established parenteral nutrition formulations. In this review, a brief overview of the parenteral lipid emulsions and the various facets in the development of injectable lipid emulsions for drug delivery has been discussed.Author: Ketan Hippalgaonkar, Soumyajit Majumdar, Viral Kansara
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