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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039753/
Ocular drug delivery through hydrogel contact lenses has great potential for the treatment of ocular diseases. Previous studies showed that the loading of lipophilic vitamin E to silicone-hydrogel contact lenses was beneficial in ocular drug delivery.Author: Dasom Lee, Seungkwon Cho, Hwa Sung Park, Inchan Kwon
https://www.sciencedirect.com/science/article/pii/S093964111500260X
Dual drug delivery from vitamin E loaded contact lenses for glaucoma therapy. ... Hydrophilic drugs such as timolol and dorzolamide have negligible solubility in the vitamin E aggregates, and the drug molecules are forced to diffuse along a tortuous, longer pathway in the lens. Our results here show that about 20% vitamin E incorporation ...Author: Kuan-Hui Hsu, Blanca E. Carbia, Caryn Plummer, Anuj Chauhan
https://www.sciencedirect.com/science/article/pii/S0142961210001456
Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing Vitamin E diffusion barriers ... which lead to differences in drug binding to the hydrophilic component rich phases in the lenses. ... C. Alvarez-LorenzoThe nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol ...Author: Cheng-Chun Peng, Jinah Kim, Anuj Chauhan
https://www.drugs.com/mtm/timolol.html
Aug 08, 2019 · Timolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).. Timolol is used to treat hypertension (high blood pressure).Timolol is sometimes given with other blood pressure medication. Timolol is also used to lower the risk of death after a heart attack, or to lower the risk of having another heart attack.Drug class: Non-cardioselective beta blockers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171267/
Apr 08, 2011 · Hydrogels have a tremendous number of biomedical applications including drug delivery. 62 One of the greatest challenges with using hydrogels for drug delivery is that water-soluble drugs, such as those likely to be used in glaucoma, tend to elute very quickly from the highly hydrated polymer networks. 63 However, soft contact lenses ...Author: Erin Baker Lavik, M. H. Kuehn, Y. H. Kwon
https://www.nature.com/articles/srep34194
Sep 28, 2016 · Ocular drug delivery through hydrogel contact lenses has great potential for the treatment of ocular diseases. ... and two hydrophilic glaucoma drugs (timolol and brimonidine) to the lenses by 37 ...Author: Dasom Lee, Seungkwon Cho, Hwa Sung Park, Inchan Kwon
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