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https://www.cell.com/abstract/S0092-8674(09)00446-2
Jun 12, 2009 · Therapeutic strategies based on modulation of microRNA (miRNA) activity hold great promise due to the ability of these small RNAs to potently influence cellular behavior. In this study, we investigated the efficacy of a miRNA replacement therapy for liver cancer. We demonstrate that hepatocellular carcinoma (HCC) cells exhibit reduced expression of miR-26a, a miRNA that is …Author: Janaiah Kota, Raghu R. Chivukula, Kathryn A. O'Donnell, Erik A. Wentzel, Chrystal L. Montgomery, Hun...
https://www.ncbi.nlm.nih.gov/pubmed/19524505
Jun 12, 2009 · Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Kota J(1), Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT.Author: Janaiah Kota, Raghu R. Chivukula, Kathryn A. O'Donnell, Erik A. Wentzel, Chrystal L. Montgomery, Hun...
https://www.sciencedirect.com/science/article/pii/S0092867409004462
AAV-Mediated miR-26a Delivery Suppresses Tumorigenesis in tet-o-MYC; LAP-tTA Mice (A) Timeline of miR-26a therapeutic delivery experiment. (B) Gross tumor burden of livers from miR-26a-treated and control animals, as determined by quantification of tumor area using the ImageJ software package.Author: Janaiah Kota, Raghu R. Chivukula, Kathryn A. O'Donnell, Erik A. Wentzel, Chrystal L. Montgomery, Hun...
https://www.researchgate.net/publication/26290290_Therapeutic_microRNA_Delivery_Suppresses_Tumorigenesis_in_a_Murine_Liver_Cancer_Model
Request PDF Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model Therapeutic strategies based on modulation of …
https://www.cell.com/cell/pdf/S0092-8674(09)00446-2.pdf
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model Janaiah Kota,1 Raghu R. Chivukula,2 Kathryn A. O’Donnell,3,4 Erik A. Wentzel,2 Chrystal L. Montgomery,1 Hun-Way Hwang, 2Tsung-Cheng Chang, Perumal Vivekanandan,5 Michael Torbenson,5 K. Reed Clark,1,7 Jerry R. Mendell,1 ,7 8 *and Joshua T. Mendell2 4 6 1Center for Gene Therapy, The Research …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498809/
Jul 05, 2017 · Our microRNA delivery system provides the tool for systemic administration of microRNAs that can inhibit liver metastasis. Our findings suggest a potential therapeutic strategy that combines tumor-suppressive microRNA with conventional cytotoxic chemotherapies for the treatment of liver metastatic disease.Author: Go Oshima, Nining Guo, Chunbai He, Melinda E. Stack, Christopher Poon, Abhineet Uppal, Sean C. Wight...
https://indiana.pure.elsevier.com/en/publications/therapeutic-microrna-delivery-suppresses-tumorigenesis-in-a-murin
Jun 12, 2009 · TY - JOUR. T1 - Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model. AU - Kota, Janaiah. AU - Chivukula, Raghu R.Author: Janaiah Kota, Raghu R. Chivukula, Kathryn A. O'Donnell, Erik A. Wentzel, Chrystal L. Montgomery, Hun...
https://www.nature.com/articles/nrd.2016.246
Feb 17, 2017 · Two of the major focus areas in the development of miRNA therapeutics are enhancing the in vivo stability of therapeutic RNA molecules and designing optimal delivery systems for …Author: Rajesha Rupaimoole, Frank J. Slack
https://www.semanticscholar.org/paper/Therapeutic-microRNA-Delivery-Suppresses-in-a-Liver-Kota-Chivukula/eaecbd1cd9655966365e9f756523295afa1cc7b6
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model @article{Kota2009TherapeuticMD, title={Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model}, author={Janaiah Kota and Raghu R. Chivukula and Kathryn A O'donnell and Erik A. Wentzel and Chrystal L. Montgomery and Hun-Way Hwang ...
https://www.sciencedirect.com/science/article/pii/S1525001617301648
In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases ... (an adhesion, invasion, migration [AIM] phenotype) and suppresses lung metastasis in an experimental model. 7 To test the use of microRNAs as a potential therapeutic ... Our microRNA delivery system provides the tool for systemic administration of ...Author: Go Oshima, Nining Guo, Chunbai He, Melinda E. Stack, Christopher Poon, Abhineet Uppal, Sean C. Wight...
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