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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098646/
May 02, 2011 · Therapeutic Delivery of mRNA: The Medium Is the Message R Scott McIvor 1 1 Center for Genome Engineering, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USAAuthor: R Scott McIvor
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31877-9
May 01, 2011 · Therapeutic Delivery of mRNA: The Medium Is the Message. Messenger RNA (mRNA) has several advantages over DNA for gene transfer and expression, including the lack of any requirement for nuclear localization or transcription and the nearly negligible possibility of genomic integration of the delivered sequence.Author: R Scott McIvor
https://experts.umn.edu/en/publications/therapeutic-delivery-of-mrna-the-medium-is-the-message
Therapeutic delivery of mRNA : The medium is the message. / Mc Ivor, R S. In ... . 822-823. Research output: Contribution to journal › Comment/debate. Mc Ivor, RS 2011, ' Therapeutic delivery of mRNA: The medium is the message ', Molecular Therapy, vol. 19, no. 5, pp ... Therapeutic delivery of mRNA. T2 - The medium is the message. AU - Mc ...Author: R S Mc Ivor
http://europepmc.org/articles/PMC3098646
May 01, 2011 · Therapeutic delivery of mRNA: the medium is the message. R Scott McIvor Center for Genome Engineering, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA.
https://www.researchgate.net/publication/51088813_Therapeutic_Delivery_of_mRNA_The_Medium_Is_the_Message
Therapeutic Delivery of mRNA: The Medium Is the Message. mt is a cross-disciplinary biomedical journal devoted to publishing the most exciting advances in pharmacology and therapeutics, as they pertain to advances in translational and clinical medicine. It is recognized as one of the most prestigious journals in the field.
https://www.nature.com/articles/s41467-018-06936-1
Oct 29, 2018 · This study opens new avenues in cell specific delivery of mRNA molecules and ultimately might introduce IL-10 mRNA as a novel therapeutic modality to inflammatory bowel diseases. ResultsAuthor: Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas R...
https://phys.org/news/2018-07-materials-delivery-therapeutic-messenger-rna.html
Jul 16, 2018 · Unlike DNA, mRNA is not permanently inserted into a cell's genome, so it could be used to produce a therapeutic protein that is only needed temporarily. It can also be used to produce gene-editing proteins that alter a cell's genome and then disappear, minimizing the risk of off-target effects.
https://www.sciencedirect.com/science/article/pii/S1748013218301099
In the past, the in vivo delivery of mRNA therapeutics was considered as a major bottleneck. However, very recently it has been demonstrated that in vivo delivery issues like low cellular uptake and in vivo degradation by nucleases can be overcome by formulating the therapeutic mRNA into nanoparticles.Author: Zifu Zhong, Séan Mc Cafferty, Francis Combes, Hanne Huysmans, Joyca De Temmerman, Arlieke Gitsels, D...
https://www.sciencedirect.com/science/article/pii/S0168365915302832
The therapeutic potential of mRNA as a versatile strategy for treating a number of diseases or enabling protein-based immunotherapy underscores the need for continued development and refinement of mRNA delivery strategies.Author: Kevin J. Kauffman, Matthew J. Webber, Matthew J. Webber, Daniel G. Anderson
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(17)30114-4
Jun 07, 2017 · Modified mRNA (modRNA) is a new technology in the field of somatic gene transfer that has been used for the delivery of genes into different tissues, including the heart. Our group and others have shown that modRNAs injected into the heart are robustly translated into the encoded protein and can potentially improve outcome in heart injury models.Author: Nishat Sultana, Ajit Magadum, Yoav Hadas, Jason Kondrat, Neha Singh, Elias Youssef, Damelys Calderon...
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