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https://clincancerres.aacrjournals.org/content/early/2020/01/24/1078-0432.CCR-19-3717
Jan 01, 2020 · Purpose: The efficacy of antibody-based therapeutics depends on successful drug delivery into solid tumors, therefore there is a clinical need to measure intratumoral antibody distribution. This study aims to develop and validate an imaging and computation platform to directly quantify and predict antibody delivery into human head and neck cancers in a clinical study.Author: Guolan Lu, Shayan Fakurnejad, Brock A. Martin, Nynke S. van den Berg, Stan van Keulen, Naoki Nishio,...
https://www.nature.com/articles/s41598-019-55091-0
Dec 10, 2019 · Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions Skip to main content Thank you for visiting nature.com.Author: Julie Gaston, Nicolas Maestrali, Guilhem Lalle, Marie Gagnaire, Alessandro Masiero, Bruno Dumas, Tar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
These results are suggestive of the potential of RMT in enhancing therapeutic antibody delivery to the brain to reducing Aβ plaque burden in AD. The potential for antibody efflux in the brain to blood direction must also be taken into consideration when developing antibody-based diagnostic and therapeutic strategies for CNS cancers.Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://evidentic.com/therapeutic-antibodies/
Therapeutic antibodies are the active ingredient of drugs targeting antigens like HER2, TNF-α or CD20. For researchers, therapeutic antibodies are mostly difficult to obtain. Biopharmaceutical companies require different batches. At Evidentic you can buy therapeutic antibodies from 18 original EU-licensed drugs as aliquots or dilutions.
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00025
Realizing the potential for antibody therapy in disease treatment, progress has been made in the development of methods to deliver antibodies intracellularly. In this review, we address various platforms for delivery of antibodies and their merits and drawbacks.Author: Khushboo Singh, Wardah Ejaz, Kingshuk Dutta, S. Thayumanavan
https://www.nature.com/articles/s41551-019-0434-z
Approximately 15–40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are ...Author: Jing Wen, Di Wu, Meng Qin, Chaoyong Liu, Lan Wang, Duo Xu, Harry V. Vinters, Yang Liu, Emiko Kranz, ...
https://www.sciencedirect.com/science/article/pii/B9780323461436000257
Monoclonal antibodies are routinely used in several fields but the great challenge has been their use as therapeutic agents for the treatment of diseases, such as breast cancer, leukemia, asthma, macular degeneration, arthritis, Crohn’s disease, and transplants, among others.Author: Daniela A. Quinteros, José M. Bermúdez, Soledad Ravetti, Alicia Cid, Daniel A. Allemandi, Santiago D...
https://www.onlinelibrary.wiley.com/doi/full/10.1002/adma.201805697
Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy. Lei Han. Department of Neurosurgery, Tianjin Medical University General Hospital; Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin Neurological Institute, Tianjin, 300052 China.Author: Lei Han, Chaoyong Liu, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie...
https://www.sciencedirect.com/science/article/pii/S0896627313010350
Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle. ... Increased Antibody Delivery across the BBB Translates into Enhanced In Vivo Potency. ... the therapeutic antibody mAb31 had been shown to reduce the plaque burden at …Author: Jens Niewoehner, Bernd Bohrmann, Ludovic Collin, Eduard Urich, Hadassah Sade, Peter Maier, Petra Rue...
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