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https://www.sciencedirect.com/science/article/pii/S0169409X03002394
2. Transdermal drug delivery using microneedles. The overarching motivation for microneedles is that they can provide a minimally invasive means to transport molecules into the skin. Guided by this goal, a number of specific strategies have been employed to use microneedles for transdermal delivery.Author: Mark R Prausnitz
https://www.medicaldesignandoutsourcing.com/microneedle-technology-transdermal-drug-delivery/
Jun 23, 2016 · A subset of transdermal drug delivery, microneedle technology using liquid silicone rubber (LSR), provides stronger, smaller polymers that are more stable and can last longer through multiple uses. This is helping to drive the growth of the transdermal drug delivery market. We look now at manufacturing and engineering progression as part of this growth.
https://www.dermarollershop.com/blog/microneedles-transdermal-drug-delivery-dynamic-duo/
One of the major uses of microneedles is transdermal drug delivery. But the success of this route has severely limited by the inability of some medications to enter the skin at a therapeutically useful rate. Just recently, there is an increasing use of micron-scale needles in increasing the skin permeability. It has been shown that […]
https://www.ondrugdelivery.com/wp-content/uploads/2017/05/1060_GF_ONdrgDelivery_Issue-56_-transdermal_MR.pdf
Microstructured Transdermal System with hollow microneedles. Figure 3: 3M Holllow Microstructured Transdermal System, pPolymer microneedle array with 12 hollow microneedles, each approximately 1500 µm. “The target delivery volume of 3M Hollow Microstructured Transdermal System is 0.5-2 mL, making it a viable delivery
https://www.sciencedirect.com/science/article/pii/S0142961207010605
Dissolving microneedles for transdermal drug delivery. (a) Microneedle master-structure (600 μm in height and 300 μm wide at base) used to mold dissolving microneedles made of (b) CMC, (c) amylopectin and (d) BSA. The master-structure was imaged by scanning electron microscopy and the molded microneedles were imaged by brightfield microscopy.Author: Jeong Woo Lee, Jung-Hwan Park, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · An interesting and useful approach is the use of near-infrared (NIR) light-responsive polymer-nanostructure composite microneedles used for on-demand transdermal drug delivery . Silica-coated lanthanum hexaboride (LaB 6 @SiO 2 ) nanostructures were incorporated into polycaprolactone microneedles, serving as a near infrared ray absorber absorber ...Author: Kevin B. Ita
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings.Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.deltamodtech.com/blog/transdermal-innovation-why-we-need-microneedle-patches-to-be-an-industry-disruptor/
It seemed like the ideal delivery method for vaccines and antibiotics, but the problem was the mechanism. How could photosensitized compounds be administered in a safe, easy-to-use manner that was also cost-effective? The sticking point: Needles. Dr. Donnelly had been researching the delivery of photosensitizing compounds through microneedles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293299/
This approach has demonstrated increased transdermal delivery of small-molecule drugs, proteins, DNA, and vaccines [4, 5]. One approach involves pretreatment of skin with microneedles, followed by application of a transdermal patch for extended drug delivery through the permeabilized skin . Another approach involves coating or encapsulating ...Author: Jeong Woo Lee, Jung-Hwan Park, Mark R. Prausnitz
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