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https://www.sciencedirect.com/science/article/pii/S016836599900098X
The delivery of BCNU to brain tumors 1. Introduction. BCNU (1-3-bis (2-chloroethyl)-1-nitrosourea... 2. Mathematical model. The model geometry ( Fig. 3. Results and discussion. The simulated pressure and velocity profiles... 4. Conclusions. Simulation studies on BCNU delivery to tumors have been ...Author: Chi-Hwa Wang, Jian Li, Chee Seng Teo, Timothy Lee
https://www.academia.edu/9871841/The_delivery_of_BCNU_to_brain_tumors
The delivery of BCNU to brain tumors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936295/
Feb 12, 2014 · The application of MB-FUS to enhance BCNU delivery to brain tumors therefore appears to suppress tumor growth as well as prolong animal survival relative to the use of …Author: Hao-Li Liu, Ching-Hsiang Fan, Chien-Yu Ting, Chih-Kuang Yeh
https://core.ac.uk/display/48711001
Abstract. 10.1016/S0168-3659(99)00098-XJournal of Controlled Release611-221-41JCREAuthor: C.-H. Wang, J. Li, C.S. Teo and T. Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483039/
Mar 05, 2015 · At the time the first polymeric delivery system was being developed for primary malignant brain tumors, BCNU was widely considered to be the most effective systemic chemotherapy for HGG. 41 – 43 For this reason, BCNU was chosen as the best candidate for locally delivered chemotherapy. BCNU is a nitrosourea that has shown activity against gliomas and other solid tumors.Author: Scott D. Wait, Roshan S. Prabhu, Stuart H. Burri, Tyler G. Atkins, Anthony L. Asher
https://dtp.cancer.gov/timeline/flash/success_stories/S1_Carmustine.htm
The physiological disposition of the carcinostatic 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) in man and animals. Clin Pharmacol Ther 1967;8:566–577. 2 Sipos EP, Tyler B, Piantadosi S, Burger PC, Brem H. Optimizing interstitial delivery of BCNU from controlled release polymers for the treatment of …
http://chemocare.com/chemotherapy/drug-info/bicnu.aspx
There is a form of this medication (Gliadel® wafer) that can be placed and left in the cavity after surgical removal of a brain tumor. The carmustine wafer allows for delivery of the drug directly to the site of the brain tumor. (See separate listing "carmustine wafer" for more details regarding this formulation).
https://link.springer.com/article/10.1007/s002800050588
Feb 01, 1997 · The 20% BCNU-loaded 20:80 polymer achieved the best balance of toxicity and antitumor efficacy, yielding a 75% long-term survival rate. Further evaluation of this polymer in monkeys suggests that it might be used with acceptable toxicity.Author: Eric P. Sipos, Betty Mae Tyler, Steven Piantadosi, Peter C. Burger, Henry Brem
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