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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.researchgate.net/publication/226112178_The_Conjunctival_Barrier_in_Ocular_Drug_Delivery
Request PDF The Conjunctival Barrier in Ocular Drug Delivery Within the context of topical and local drug delivery to the eye, the mammalian conjunctiva functions as a unique biological barrier.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874841/
Feb 27, 2018 · Ocular drug delivery is challenging due to the presence of anatomical and physiological barriers. These barriers can affect drug entry into the eye following multiple routes of administration (e.g., topical, systemic, and injectable). Topical administration ...Author: Rinda Devi Bachu, Pallabitha Chowdhury, Zahraa H. F. Al-Saedi, Pradeep K. Karla, Sai H. S. Boddu
https://www.sciencedirect.com/science/article/pii/B9781907568862500010
1.3. Barriers to ocular drug delivery. Ophthalmic drugs are available as solutions, suspensions and ointments, which are primarily administered topically. Other routes of drug delivery to the eye are oral, intravenous, intravitreal, subconjunctival and periocular injections or implants . A challenging task in drug delivery is to overcome ocular ...Author: Kishore Cholkar, Supriya Reddy Dasari, Dhananjay Pal, Ashim K. Mitra
https://link.springer.com/chapter/10.1007%2F978-0-387-74901-3_13
Abstract. Within the context of topical and local drug delivery to the eye, the mammalian conjunctiva functions as a unique biological barrier. Various model systems as in vitro tools have been refined and validated over the years to assess drug absorption across the conjunctiva.Author: Hovhannes J. Gukasyan, Kwang-Jin Kim, Vincent H.L. Lee
https://link.springer.com/chapter/10.1007%2F978-1-59745-375-2_21
Ocular drug delivery, particularly to the posterior segment, is one of the most challenging tasks currently facing ocular drug-delivery scientists. Ophthalmic drugs are primarily administered by the topical route to treat ocular viral and bacterial infections, glaucoma, inflammations, and immunosuppression.Author: Sriram Gunda, Sudharshan Hariharan, Nanda Mandava, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/S0939641105000159
We would like to point out the fact that these latter subject matters are not directly relevant for conjunctival drug transport, but may explain the formidable role of conjunctiva in ocular drug delivery. 2. Barrier properties of the conjunctivaAuthor: Ken-ichi Hosoya, Vincent H.L. Lee, Kwang-Jin Kim
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
https://www.slideshare.net/sagarsavale1/ocular-drug-delivery-system-odds-62796410
Jun 07, 2016 · “The Novel approach of drug delivery system in which drug can Instilled on the cull de sac cavity of eye is known has Ocular drug delivery system”. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
https://clinicalgate.com/ocular-drug-delivery/
Designing ocular drug delivery formulations requires an understanding of what can be tolerated by the eye. Physiological and biochemical mechanisms exist to protect the eye from harmful stimuli. While these mechanisms are protective, they do sometimes present a barrier to drug absorption. The lacrimal system of the eye is extremely dynamic.
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