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https://www.researchgate.net/publication/51546325_The_Application_of_Delivery_Systems_for_DNA_Methyltransferase_Inhibitors
The Application of Delivery Systems for DNA Methyltransferase Inhibitors Article · Literature Review in BioDrugs 25(4):227-42 · August 2011 with 27 Reads How we measure 'reads'
https://link.springer.com/article/10.2165/11592770-000000000-00000
Aug 16, 2012 · Further improvements in the delivery systems for these drugs could overcome the issues associated with inefficient bioavailability, whilst facilitating the administration of combinations of demethylating agents and histone deacetylase inhibitors to enhance efficacy. ... The Application of Delivery Systems for DNA Methyltransferase Inhibitors ...Author: Sue Ping Lim, Paul Neilsen, Raman Kumar, Andrew Abell, David F. Callen
https://core.ac.uk/display/12792287
The application of delivery systems for DNA methyltransferase inhibitors . By S. Lim, P ... their broader clinical application is restricted by cytotoxicity, nonspecific targeting, structural instability, catabolism, and poor bioavailability. Further improvements in the delivery systems for these drugs could overcome the issues associated with ...Author: Sue Ping Lim, Paul Neilsen, Raman Kumar, Andrew Abell, David F. Callen
https://www.ncbi.nlm.nih.gov/pubmed/23898051
The DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine are the most successful epigenetic drugs to date and are still the most widely used as epigenetic modulators, even though their application for oncological diseases is restricted by their relative toxicity and poor chemical stability.Author: Gnyszka A, Jastrzebski Z, Flis S
https://www.sciencedirect.com/science/article/pii/S0165614704002548
The pharmacological inhibition of DNA methyltransferases provides novel opportunities for the therapy of human cancers. Several Phase III trials of DNA methyltransferase inhibitors have been completed successfully, but the efficacy of these compounds appears to be compromised by their lack of specificity.Author: Bodo Brueckner, Frank Lyko
https://www.ncbi.nlm.nih.gov/pubmed/26303417/
DNA Methyltransferases Inhibitors from Natural Sources. Zwergel C, Valente S(1), Mai A(2). Author information: (1)Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. [email protected]: Clemens Zwergel, Sergio Valente, Antonello Mai
https://www.researchgate.net/publication/312524630_DNA_Methyltransferase_Inhibitors
Classes of drugs such as histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors are currently being used to target these epigenetic ... [Show full abstract] changes. Recently ...
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/dna-methyltransferase
W.W. Weber, in Comprehensive Medicinal Chemistry II, 2007. 1.04.3.3.1 The Dnmt1 family. DNA methyltransferase is a comparatively large molecule of approximately ∼190 kDa containing 1620 amino acids. Enzymatically catalyzed DNA methylation is a covalent modification of DNA in which a methyl group is transferred from S-adenosylmethionine to the C-5 position of cytosine.
https://pubs.acs.org/doi/10.1021/jo034248t
The Application of Delivery Systems for DNA Methyltransferase Inhibitors. BioDrugs 2011, 25 (4) , 227-242. DOI: 10.2165/11592770-000000000-00000. Feng-Feng Cai, Corina Kohler, Bei Zhang, Ming-Hong Wang, Wei-Jie Chen, Xiao-Yan Zhong. Epigenetic Therapy for Breast Cancer.Author: Ivette C. Pina, Jeffrey T. Gautschi, Gui-Yang-Sheng Wang, Miranda L. Sanders, Francis J. Schmitz, Su...
https://en.wikipedia.org/wiki/DNMT
Three active DNA methyltransferases have been identified in mammals. They are named DNMT1, DNMT3a, and DNMT3b. A fourth enzyme previously known as DNMT2 is not a DNA methyltransferase (see below). DNMT3L is a protein closely related to DNMT3a and DNMT3b in structure and critical for DNA methylation, but appears to be inactive on its own.Symbol: N6_Mtase
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