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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839649/
Nov 06, 2019 · Delivery of nucleic acids into solid tumor environments remains a pressing challenge. This study examines the ability of macrophages to horizontally transfer small interfering RNA (siRNA) lipoplexes to cancer cells. Macrophages are a natural candidate …Author: Elizabeth C. Wayne, Christian Long, Matthew J. Haney, Elena V. Batrakova, Tina M. Leisner, Leslie V....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150469/
Mar 24, 2014 · Finally, since hypoxia is one of the characteristics of drug-resistant cancers, hypoxia-targeted co-delivery of a chemotherapeutic drug and siRNA against the hypoxia principal effector, hypoxia inducible factor 1α, could allow relapse-free destruction of some of the most aggressive tumors.Author: Federico Perche, S. Biswas, T. Wang, L. Zhu, L. Zhu, V. Torchilin
https://www.sciencedirect.com/science/article/pii/S007668790965014X
RNA interference provides a powerful technology for silencing any single protein within a target cell. Therapeutic applications of small interfering RNAs (siRNAs), however, require vehicles for stable and efficient delivery of these nucleic acid molecules, both in vitro and in vivo.Targeted lipoplexes have been used as a promising system to mediate siRNA delivery and to achieve gene silencing.Author: Ana Cardoso, Sara Trabulo, João Nuno Moreira, Nejat Düzgüneş, Maria C. Pedroso de Lima
https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.201900582
Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer Elizabeth C. Wayne,* Christian Long, Matthew J. Haney, Elena V. Batrakova, Tina M. Leisner, Leslie V. Parise, and Alexander V. Kabanov* DOI: 10.1002/advs.201900582 delivery into …Author: Elizabeth C. Wayne, Christian Long, Matthew J. Haney, Elena V. Batrakova, Tina M. Leisner, Leslie V....
https://onlinelibrary.wiley.com/doi/10.1002/advs.201900582
Cationic siRNA lipoplexes are beneficial packaging systems for nonviral siRNA delivery. 12-14 Cationic lipids form complexes with negatively charged siRNA via electrostatic interaction. 15, 16 Optimization of the complex formation parameters (such as lipid composition, ratio to siRNA, mixing temperature, etc.) has led to efficient delivery into ...Author: Elizabeth C. Wayne, Christian Long, Matthew J. Haney, Elena V. Batrakova, Tina M. Leisner, Leslie V....
https://www.researchgate.net/publication/268077891_Targeted_Decationized_Polyplexes_for_siRNA_Delivery
In conclusion, targeted decationized polyplexes are safe and stable carriers that interact with the targeted cells and rapidly disassemble upon cell entry making them promising siRNA delivery systems.
https://www.researchgate.net/publication/38089148_Chapter_14_Targeted_Lipoplexes_for_siRNA_Delivery
Targeted lipoplexes have been used as a promising system to mediate siRNA delivery and to achieve gene silencing. Electrostatic association of transferrin (Tf) to cationic liposomes enhances the ...
https://pubs.acs.org/doi/full/10.1021/mp900094j
siRNA delivery to specific cell types is a key challenge for turning siRNA into therapeutics. A number of cell specific ligands including polysaccharide, antibody, antibody fragment, and peptide have been employed to achieve targeted delivery of siRNA.
https://www.sciencedirect.com/science/article/pii/B9780123942951000044
Targeted siRNA Delivery. Targeted siRNA delivery systems for cancer are a promising new class of experimental therapeutics with the potential to revolutionize medicine with their increased efficiency and relatively low toxicity compared to conventional drugs.Author: Maneesh Gujrati, Zheng-Rong Lu
https://www.liebertpub.com/doi/abs/10.1089/oli.2008.0168
Cationic hyaluronic acid (HA)-modified DOTAP/DOPE liposomes were designed for the targeted delivery of anti-telomerase siRNA to CD44 receptor-expressing lung cancer cells. DOTAP/DOPE liposomes modified with 1%–20% (w/w) HA-DOPE conjugate were obtained by the ethanol injection method.Author: Sebastian Taetz, Amélie Bochot, Claudio Surace, Silvia Arpicco, Jack-Michel Renoir, Ulrich F. Schaef...
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