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https://link.springer.com/chapter/10.1007/978-1-4419-9920-7_14
Jun 20, 2011 · Microneedles can selectively target intraocular tissues by delivering drug formulations within the cornea, sclera, and suprachoroidal space in a minimally invasive manner.Author: Samirkumar R. Patel, Henry F. Edelhauser, Mark R. Prausnitz
https://www.researchgate.net/publication/226901243_Targeted_Drug_Delivery_to_the_Eye_Enabled_by_Microneedles
Targeted Drug Delivery to the Eye Enabled by Microneedles. Drug delivery targeted to specific tissues within the eye represents an important advance over conventional methods of topical and injectable delivery that have poor specificity for particular ocular tissues requiring therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453494/
Dec 01, 2016 · A lthough drug delivery targeted to the eye is in widespread use, targeting drug delivery within the eye has received less attention. Indeed, topical eye drops generally target the anterior segment and intravitreal injections target the posterior segment, but diseases are usually more localized within these regions of the eye.Author: R PatelSamirkumar, R PrausnitzMark
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232008/
This study introduced the use of targeted drug delivery to the supraciliary space by using a microneedle and demonstrated dramatic dose sparing of antiglaucoma therapeutic agents compared to topical eye drops.Author: Yoo C. Kim, Henry F. Edelhauser, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/abs/pii/S0024320519308343
Nov 15, 2019 · Microneedles (MNs) as an alternate novel delivery system facilitate drug delivery to various ocular diseases with promising approaches in healthcare. Advances in pharmaceutical technology have made MNs provide localized, effective, less invasive and targeted drug delivery in the eye.Author: Pallavi Gupta, Khushwant S. Yadav
https://www.ncbi.nlm.nih.gov/pubmed/27485251
It discusses research carried out in the field of MNs, to date. Expert opinion: MNs can aid in localization of drug delivery systems within the selected ocular tissue. And, hold the potential to revolutionize the way drug formulations are administered to the eye.Author: Raghu Raj Thakur Singh, Ismaiel Tekko, Kathryn McAvoy, Hannah McMillan, David Jones, Ryan F. Donnell...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038673/
Considering the four characteristics of an ideal posterior segment drug delivery system, suprachoroidal delivery using microneedles has the promise to be simple, minimally invasive, targeted, and able to achieve sustained release by injecting nanoparticles and microparticles encapsulating drug for slow release.Author: Samirkumar R. Patel, Angela S. P. Lin, Henry F. Edelhauser, Mark R. Prausnitz
http://drugdelivery.chbe.gatech.edu/Papers/2011/Patel%20Pharm%20Res%202011.pdf
microneedles can provide a minimally invasive method to inject nanoparticles and microparticles into the supra- choroidal space for drug delivery to the back of the eye. Hollow microneedles are needles of micron dimensions that
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231993/
Microneedles coated with bevacizumab for targeted intrastromal delivery. (a) A single microneedle (arrow) mounted on a handle for manual application is shown next to a liquid drop from a conventional eye dropper. Scale bar: 1 mm. (b) Magnified view of ...Author: Yoo C. Kim, Hans E. Grossniklaus, Henry F. Edelhauser, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0168365917310556
Microneedles is the technique of drug delivery enhancement, which was primarily designed for facilitating percutaneous drug delivery. Started from the development of simple solid microneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has progressed in various modifications such as hollow, coated, dissolving and ...Author: Alexey S. Rzhevskiy, Thakur Raghu Raj Singh, Ryan F. Donnelly, Yuri G. Anissimov
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