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https://www.sciencedirect.com/science/article/pii/S1773224719305246
The tool to solve the issue with current clinical treatment of RA is use of targeted drug delivery strategies. As the targeted drug delivery system promises the specific targeting to inflamed joint and delivery of therapeutic targets, there by overcoming the systemic side effects.Author: Ayesha Syed, V. Kusum Devi
https://www.researchgate.net/publication/324580086_Recent_approaches_for_targeted_drug_delivery_in_rheumatoid_arthritis_diagnosis_and_treatment
Rheumatoid arthritis (RA) is another disease that has seen the development of NP-based systems for targeted drug delivery at the cellular level [97] [98][99][100]. RA is a chronic inflammatory ...
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2018.1433680
May 23, 2018 · Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that selectively attacks human joints. The common non-targeted treatment approaches lead to obvious side effect and systemtic complication for RA patients. Therefore, targeted drug delivery for treatment of RA has gained much attetntion in the past few years.Author: Xun Feng, Yang Chen
https://www.researchgate.net/publication/221922361_The_Development_of_Targeted_Drug_Delivery_Systems_for_Rheumatoid_Arthritis_Treatment
Download Citation On Jan 18, 2012, Rebecca A. Bader and others published The Development of Targeted Drug Delivery Systems for Rheumatoid Arthritis Treatment Find, read and cite all the ...
http://cdn.intechopen.com/pdfs/26077.pdf
The Development of Targeted Drug Delivery Systems for Rheu matoid Arthritis Treatment 113 The pharmacokinetic profiles of most DMAR Ds are unfavorable (Tarner & Muller-Ladner, 2008). For example, the bioavailability, peak serum concentration, and half life of orally administered methotrexate varies considerably between patients.
https://acrabstracts.org/abstract/targeted-drug-delivery-using-a-novel-joint-homing-peptide-for-arthritis-therapy/
Nov 11, 2019 · Thus, there is a need for targeted drug delivery methods to direct the drugs primarily to the inflamed joints. Methods: We developed a peptide-directed liposomal drug delivery system to deliver dexamethasone (DEX) to arthritic joints of rats with adjuvant-induced (AA) arthritis. The peptide ART-2 shows preferential homing to inflamed joints ...
https://www.sciencedirect.com/science/article/pii/S0168365916312767
At the same time, encapsulating PD in micelles reduces its myelo- and hepatotoxicity. This pH-sensitive drug delivery system shows potential for targeted glucocorticoid-based treatment of rheumatoid arthritis, and it may be adaptable to treating other inflammatory diseases.Author: Chunhong Li, Hanmei Li, Qin Wang, Meiling Zhou, Man Li, Tao Gong, Zhirong Zhang, Xun Sun
http://biomedpharmajournal.org/vol12no1/novel-drug-delivery-systems-for-rheumatoid-arthritis-an-approach-to-better-patient-compliance/
The development of targeted drug delivery system for rheumatoid arthritis treatment.Syracuse Biomaterial institute. syracuse university. 2012. Williams A. S., Camilleri J. P and Williams B. D. Suppression of adjuvant-induced arthritis by liposomally conjugated methotrexate in the rat.Author: Sangeeta Mohanty, Sthitapragnya Panda, Aslesha Bhanja, Abhisek Pal, Si Sudam Chandra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800699/
Rheumatoid arthritis (RA) is a common inflammatory disease characterized by progressive bone and cartilage destruction, resulting in severe functional limitations, shortened lifespan, and increased mortality rates. ... The development of a targeted nanocarrier system for sustained drug delivery in RA is thus highly desirable. In addition ...
https://www.ncbi.nlm.nih.gov/pubmed/18754751
Drug delivery systems for the treatment of rheumatoid arthritis. ... Targeted drug delivery and prolongation of bioavailability would alleviate this issue significantly. This article, therefore, reviews a selection of studies that report promising strategies for joint specific delivery of antiarthritic drugs.Author: Ingo H Tarner, Ulf Müller-Ladner
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