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https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201909345
The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum‐based DNA intercalator, 56MESS.Author: Tiantian Wu, Tiantian Wu, Jianbing Liu, Manman Liu, Shaoli Liu, Shaoli Liu, Shuai Zhao, Shuai Zhao, ...
https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc01391a#!
A multifunctional nanobody–drug conjugate (NDC) was constructed in this work for the targeted delivery of a platinum prodrug and an MRI contrast agent. The NDC can be specifically internalized into EGFR positive cancer cells, resulting in higher therapeutic effect and lower side-effects relative to cisplatin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792284/
Mar 09, 2016 · The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. ... Platinum(IV) agents with axially coordinated bioactive peptides have been designed and prepared with the aim of targeted drug delivery to tumors.Author: Timothy C. Johnstone, Kogularamanan Suntharalingam, Stephen J. Lippard
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201900418
Dec 11, 2019 · However, there are few stimuli‐responsive micro/nanomotor systems to enhance the drug delivery efficiency and reduce side effects by the spatiotemporal controllability. Here, a degradable nanomotor is first fabricated for targeted drug delivery using a platinum (Pt)‐deposited complex of calcium carbonate and cuccurbit[6] ...Author: Hyunsik Choi, Byung Woo Hwang, Kyeng Min Park, Ki Su Kim, Sei Kwang Hahn
https://www.sciencedirect.com/science/article/pii/S0079670018301667
However, their extensive systemic toxicity and the drug resistance acquired by cancer cells limit the applications of platinum drugs. Modern nanobiotechnology provides the possibility for targeted delivery of platinum drugs to the tumor site, thereby minimizing toxicity and optimizing the efficacies of the drugs.Author: Haihua Xiao, Lesan Yan, Elizabeth M. Dempsey, Wantong Song, Ruogu Qi, Wenliang Li, Yubin Huang, Xiab...
https://www.researchgate.net/publication/284279759_Targeted_Drug_Delivery_System_for_Platinum-based_Anticancer_Drugs
Targeted Drug Delivery System for Platinum-based Anticancer Drugs Article in Mini Reviews in Medicinal Chemistry 16(999) · November 2015 with 76 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582270/
Nov 11, 2008 · We therefore devised a strategy for cisplatin therapy in prostate cancer based on mechanisms that target critical molecular pathways of prostate tumors and that employ platinum chemistry and delivery vehicles for such targeting. Targeted controlled release drug delivery systems have the potential to induce dramatic and durable clinical responses.Author: Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Stephen J. Lippard
https://www.researchgate.net/publication/335016103_A_Nanobody-Conjugated_DNA_Nanoplatform_for_Targeted_Platinum_Drug_Delivery
A Nanobody‐Conjugated DNA Nanoplatform for Targeted Platinum Drug Delivery Article in Angewandte Chemie 131(40) · August 2019 with 59 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0223523420301963
3. Drug targeting and delivery systems. Selective drug delivery is an important approach with great potential for overcoming problems associated with the systemic toxicity of chemotherapy, in particular, platinum-based chemotherapy [23,24].Targeted drug therapy has two advantages over conventional chemotherapy: preventing damage to normal tissues and reducing drug resistance [].
https://www.tandfonline.com/doi/abs/10.1080/17425247.2017.1307338
Oct 14, 2016 · Introduction: Platinum anticancer drugs are effective against a wide range of tumors, though their severe adverse effects and resistance remain unresolved.A breakthrough in these drawbacks could be achieved by using polymeric micelles, i.e. nanoassemblies having a drug loaded core and a protective hydrophilic shell, incorporating platinum drugs for tumor-targeted delivery.Author: Yuki Mochida, Horacio Cabral, Kazunori Kataoka
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