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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140134/
Dec 01, 2010 · Effective delivery of therapeutic agents into the brain can greatly improve the treatments of neurological and neurodegenerative diseases. Application of focused ultrasound facilitated by microbubbles has shown the potential to deliver drugs across the blood–brain barrier into targeted sites within the brain noninvasively.Author: Cheri X Deng
https://www.future-science.com/doi/10.4155/tde.10.66
Dec 03, 2010 · Effective delivery of therapeutic agents into the brain can greatly improve the treatments of neurological and neurodegenerative diseases. Application of focused ultrasound facilitated by microbubbles has shown the potential to deliver drugs across the blood–brain barrier into targeted sites within the brain noninvasively.Author: Cheri X Deng
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
Several methods have been developed to overcome the BBB and allow drugs into the brain. Surgical approaches are the most effective for direct drug delivery into the region of interest. Specific brain regions are targeted using stereotactic coordinates and needles or pumps are used to deliver drugs by direct injection.Author: Alison Burgess, Kullervo H. Hynynen
https://www.researchgate.net/publication/51517959_Targeted_drug_delivery_across_the_blood-brain_barrier_using_ultrasound_technique
Application of focused ultrasound facilitated by microbubbles has shown the potential to deliver drugs across the blood-brain barrier into targeted sites within the brain noninvasively.Author: Cheri Deng
https://www.theengineer.co.uk/ultrasound-targeted-drug-delivery/
Using focused ultrasound with its microbubble contrast agent to deliver drugs across the blood-brain barrier (FUS-BBBD), the research team, led by Hong Chen, assistant professor of biomedical engineering at McKelvey School of Engineering and assistant professor of radiation oncology at the School of Medicine, overcame some of the uncertainty of drug delivery.
https://www.pnas.org/content/pnas/114/48/E10281.full.pdf
Focused ultrasound is currently the only method of reversible blood–brain barrier disruption for targeted drug delivery without incision or radiation. A significant challenge for its clinical translation is a lack of reliable real-time treatment control. Here a closed-loop, real-time control paradigm isAuthor: Tao Sun, Tao Sun, Yongzhi Zhang, Chanikarn Power, Phillip M. Alexander, Jonathan T. Sutton, Muna Ary...
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