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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071079/
However, efficient and biocompatible delivery methods are needed for systemic delivery of small interfering RNA (siRNA). To maintain a high level of growth, tumor cells scavenge high-density lipoprotein (HDL) particles by overexpressing its receptor: scavenger receptor type B1 (SR-B1).Author: Mian M.K. Shahzad, Mian M.K. Shahzad, Lingegowda S. Mangala, Hee Dong Han, Chunhua Lu, Justin Bottsf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · The functional mediators of RNA interference (RNAi) are small interfering RNAs (siRNA) [1, 2]. These double-stranded RNA molecules are typically 19 to 23 nucleotides in length, and consequently have a molecular weight of approximately 13 to 15 kd and 38 to 46 negative charges.Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332089/
Mar 27, 2012 · The therapeutic potential of small interfering RNAs (siRNAs) is severely limited by the availability of delivery platforms that protect siRNA from degradation, deliver it to the target cell with high specificity and efficiency, and promote its endosomal escape and cytosolic dispersion.Author: Carlee E. Ashley, Eric C. Carnes, Katharine E. Epler, David P. Padilla, Genevieve K. Phillips, Rober...
https://www.ncbi.nlm.nih.gov/pubmed/18316585
Mar 01, 2008 · Targeted delivery of small interfering RNA: approaching effective cancer therapies. Pirollo KF(1), Chang EH. Author information: (1)Department of Oncology, Georgetown University Medical Center, Washington, District of Columbia 20057-1469, USA. Three of the primary requirements for the development of effective dual-targeting therapeutic...Author: Kathleen F. Pirollo, Esther H. Chang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993214/
Targeted Small Interfering RNA-Immunoliposomes as a Promising Therapeutic Agent against Highly Pathogenic Avian Influenza A (H5N1) Virus InfectionAuthor: Kannika Khantasup, Kannika Khantasup, Phikulthong Kopermsub, Kridsada Chaichoun, Tararaj Dharakul, T...
https://onlinelibrary.wiley.com/doi/epdf/10.1002/wnan.1634
The target is specifically identified by small interfering RNAs (siRNA) which are RNA strands of 21–25 base pairs with base-complementarity to the target mRNA. Upon pairing of the activated RISC with single- stranded siRNA and the complementary mRNA site, cleavage of mRNA is initiated and the translation of the protein
https://www.nature.com/articles/nature05901
Jun 17, 2007 · A major impediment in the treatment of neurological diseases is the presence of the blood–brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain.Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://advances.sciencemag.org/content/6/13/eaaz6108.full
Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications, but there are many challenges facing its therapeutic use in vivo....
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