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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890121/
May 03, 2010 · In summary, we have shown that RVG-9dR provides a tool for targeted siRNA delivery to both microglia and macrophages in vivo. These findings overcome a critical barrier of in vivo delivery, significantly enhancing the prospect of siRNA-based therapeutics for autoimmunity and neuroinflammation.
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)31031-0.pdf
Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment Sang-Soo Kim1, Chunting Ye1, Priti Kumar2, Isaac Chiu3, Sandesh Subramanya 1, Haoquan Wu , Premlata Shankar 1 and N Manjunath 1Center of Excellence in Infectious Diseases, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839649/
Nov 06, 2019 · Delivery of nucleic acids into solid tumor environments remains a pressing challenge. This study examines the ability of macrophages to horizontally transfer small interfering RNA (siRNA) lipoplexes to cancer cells. Macrophages are a natural candidate …
https://www.sciencedirect.com/science/article/pii/S1525001616310310
In summary, we have shown that RVG-9dR provides a tool for targeted siRNA delivery to both microglia and macrophages in vivo. These findings overcome a critical barrier of in vivo delivery, significantly enhancing the prospect of siRNA-based therapeutics for autoimmunity and neuroinflammation. Materials and Methods. Peptides and siRNAs. RVG ...
https://www.sciencedirect.com/science/article/pii/S0168365911010431
To improve the outcome, the regulation of immune functions should be restricted within the tumor microenvironment by intratumoral cell-specific delivery of drugs with immune regulation properties. In the present study, we developed a tumor-associated macrophages (TAMs) targeted nucleic acid drug delivery system for use in cancer immunotherapy.
https://onlinelibrary.wiley.com/doi/10.1002/advs.201900582
Targeted delivery of RNA interference (RNAi) ... The transfer of Luc siRNA from macrophages to the cancer cells was examined by measuring the reduction of luciferase bioluminescence activity in the cancer cells following coculture with Balb/c RAW 264.7 macrophages transfected with Luc siRNA (Figure 2a).
https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.201900582
Targeted Delivery of siRNA Lipoplexes to Cancer Cells ... for nonviral siRNA delivery. [12–14] Cationic lipids form complexes with negatively charged siRNA via electrostatic interaction.[15,16] ... affect the half-life of siRNA within macrophages should be fur-ther studied.
https://www.researchgate.net/publication/41849518_Targeted_Delivery_of_siRNA_to_Macrophages_for_Anti-inflammatory_Treatment
Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment Article (PDF Available) in Molecular Therapy 18(5):993-1001 · March 2010 with 260 Reads How we measure 'reads'
https://pubs.rsc.org/en/content/articlelanding/2014/tb/c4tb01374c
Activated macrophages play an important role in the initiation and development of inflammatory diseases. The aim of this study is to develop a delivery system that targets siRNA to activated macrophages. Exploiting the presence of folate receptors on the surface of activated macrophages, folic acid was conju
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31031-0
Inflammation mediated by tumor necrosis factor-α (TNF-α) and the associated neuronal apoptosis characterizes a number of neurologic disorders. Macrophages and microglial cells are believed to be the major source of TNF-α in the central nervous system (CNS). Here, we show that suppression of TNF-α by targeted delivery of small interfering RNA (siRNA) to macrophage/microglial cells ...
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