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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249419/
Particle size and size distribution are the most important characteristics of nanoparticles. They determine the in vivo distribution, biological fate, toxicity, and targeting ability of these delivery systems. In addition, they can influence drug loading, drug release, and stability of nanoparticles.Author: Rajesh Singh, James W. Lillard, James W. Lillard
https://www.nature.com/articles/s41467-017-01830-8
Nov 23, 2017 · CD8a-targeting nanoparticles bind to T cell in vitro and in vivo. a CD8a-targeting nanoparticles (loaded with DiD), but not isotype control nanoparticles, bind to the surface of CD8 + T cells isolated from the spleen within 30 min of incubation, as assessed by flow cytometry.Author: Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Pu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. Both situations will result in an increase of therapeutic index, the margin between the doses resulting in a therapeutic efficacy (eg,...Author: Wim H De Jong, Paul Ja Borm
https://pubs.acs.org/doi/abs/10.1021/ar2000138
To achieve this purpose, biomedical researchers have developed various nanoparticles composed of organic or inorganic materials. However, the targeted delivery of these nanoparticles in animal models and patients remains a difficult hurdle for many researchers, even if they show useful properties in cell culture condition.Author: Heebeom Koo, Myung Sook Huh, In Cheol Sun, Soon Hong Yuk, Kuiwon Choi, Kwang Meyung Kim, Ick Chan Kw...
https://freepaper.me/downloads/abstract/10.1021/ar2000138
Therapy and diagnosis are two major categories in the clinical treatment of disease. Recently, the word “theranosis” has been created, combining the words to describe the implementation of these two ...
https://www.sciencedirect.com/science/article/pii/S0927776520301211
Targeted delivery platforms based on nanoparticles with great advantages including prolonged blood circulation, enhanced intratumoral accumulation, improved anticancer efficacy, and diminished side effects, might lead to great breakthroughs on osteosarcoma chemotherapy [12,13].Author: Xin Huang, Wei Wu, Wenbo Yang, Xiangcheng Qing, Zengwu Shao
https://www.sciencedirect.com/science/article/pii/S0165247817301761
Targeted drug delivery by nanomaterials is an effective anti-cancer therapeutic approach. Abstract Surgery, chemotherapy, radiotherapy, and hormone therapy are the main common anti-tumor therapeutic approaches.Author: Behdokht Bahrami, Behdokht Bahrami, Mohammad Hojjat-Farsangi, Mohammad Hojjat-Farsangi, Hamed Mohamm...
https://www.hindawi.com/journals/jnm/2016/1087250/
In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed.Author: Xiaojiao Yu, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, Zi Chen
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