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https://www.pnas.org/content/pnas/108/5/1850.full.pdf
cisplatin in oncology, and they suggest that similar strategies be undertaken to combine prodrugs with targeted delivery to syner- gistically improve safety and efficacy.Author: Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, Omid C. Farokhzad
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033286/
Feb 01, 2011 · In the present investigation, the hydrophobic Pt(IV) compound 1 was used as a prodrug for delivery of cisplatin to prostate cancer using PSMA-targeted PLGA-b-PEG-NPs. The PLGA-b-PEG-Pt(IV) prodrug NPs increased the drug MTD when compared to that of cisplatin administered in its conventional dosage form in both rat and mouse models.Author: Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, Omid C. Farokhzad
https://www.pnas.org/content/108/5/1850
Feb 01, 2011 · In the present investigation, the hydrophobic Pt(IV) compound 1 was used as a prodrug for delivery of cisplatin to prostate cancer using PSMA-targeted PLGA-b-PEG-NPs. The PLGA- b -PEG-Pt(IV) prodrug NPs increased the drug MTD when compared to that of cisplatin administered in its conventional dosage form in both rat and mouse models.Author: Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, Omid C. Farokhzad
https://www.ncbi.nlm.nih.gov/pubmed/21233423
Feb 01, 2011 · Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Dhar S(1), Kolishetti N, Lippard SJ, Farokhzad OC. Author information: (1)Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Author: Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, Omid C. Farokhzad
https://ui.adsabs.harvard.edu/abs/2011PNAS..108.1850D/abstract
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo - NASA/ADS Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today.Author: Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, Omid C. Farokhzad
http://dspace.mit.edu/handle/1721.1/65115
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Author(s) Dhar, Shanta ; Kolishetti, Nagesh ; Lippard, Stephen J. ; Farokhzad, Omid C.
https://www.researchgate.net/publication/49753945_Targeted_delivery_of_a_cisplatin_prodrug_for_safer_and_more_effective_prostate_cancer_therapy_in_vivo
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to …
https://core.ac.uk/display/4429323
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo By Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard and Omid C. Farokhzad No static citation data No static citation data Cite
https://www.wiley.com/en-us/Prodrugs+and+Targeted+Delivery%3A+Towards+Better+ADME+Properties-p-9783527326037
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in todays drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective ...
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