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https://pubs.rsc.org/en/content/articlelanding/2011/cs/c0cs00227e
Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering active forms of proteins to specific cells and organs. Intracellular protein delivery holds enormous promise for biological and medical applications,Author: Zhen Gu, Anuradha Biswas, Muxun Zhao, Yi Tang
https://www.researchgate.net/publication/51121517_ChemInform_Abstract_Tailoring_Nanocarriers_for_Intracellular_Protein_Delivery
Download Citation ChemInform Abstract: Tailoring Nanocarriers for Intracellular Protein Delivery Proteins play a crucial role in life, taking part in all vital processes in the body. In the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829369/
Gu Z, Biswas A, Zhao M, Tang Y. Tailoring nanocarriers for intracellular protein delivery. Chem. Soc. Rev. 2011; 40 (7):3638–3655. [Google Scholar] Comprehensive review on intracellular protein delivery. This is a tutorial review that talks about methodologies developed for intracellular delivery of proteins using nanocarriers.Author: Moumita Ray, Yi-Wei Lee, Federica Scaletti, Ruijin Yu, Ruijin Yu, Vincent M Rotello
https://www.pnas.org/content/113/11/2868
Mar 15, 2016 · The therapeutic potential of protein-based genome editing is dependent on the delivery of proteins to appropriate intracellular targets. Here we report that combining bioreducible lipid nanoparticles and negatively supercharged Cre recombinase or anionic Cas9:single-guide (sg)RNA complexes drives the self-assembly of nanoparticles for potent protein delivery and genome editing. The design of ...Author: Ming Wang, John Zuris, Fantao Meng, Holly Anne Rees, Shuo Sun, Pu Deng, Yong Han, Xue Gao, Dimitra P...
https://www.sciencedirect.com/science/article/pii/S0168365920300766
Cytosolic protein delivery is important for the development of protein therapeutics towards intracellular targets. Guanidyl polymers exhibit high binding affinity with cargo proteins, and thus were designed as carriers for intracellular protein delivery.Author: Jia Lv, Jia Lv, Echuan Tan, Yuqing Wang, Qianqian Fan, Jingwen Yu, Yiyun Cheng, Yiyun Cheng
https://pubs.acs.org/doi/10.1021/jacs.8b12705
Intracellular protein delivery holds enormous promise for biol. and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic diseases and imaging. This tutorial review surveys recent developments in intracellular protein …Author: Shunzhi Wang, Yijing Chen, Shuya Wang, Peng Li, Chad A. Mirkin, Omar K. Farha
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Because many protein and peptide drugs have their therapeutic targets inside cells, there is also an important task to bring these drugs into target cells without subjecting them to the lysosomal degradation. This review describes current approaches to the intracellular delivery of protein and peptide drugs.Author: Vladimir Torchilin
https://www.thno.org/v08p3872.htm
Protein therapeutics are increasingly important for the treatment of many diseases; however, intracellular protein delivery remains a considerable challenge. To address this challenge, drug nanorods have emerged as new nanocarriers for enhanced intracellular protein delivery via bypassing endo-lysosomes, which was called a “drug-delivering ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894870/
Jun 27, 2017 · The high pH-responsive CASP-3 delivery strategy was selected taking into account the gastric tumor microenvironment and the pH values found in malignant tumor cells, characterized by acidic (5.5–6.8) extracellular space and neutral (7.3–7.8) intracellular cytosol. 44,45 It should be pointed out also that while the new proof-of-concept has ...Author: Berta Esteban-Fernández de Ávila, Doris E. Ramírez-Herrera, Susana Campuzano, Pavimol Angsantikul, L...
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