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https://en.wikipedia.org/wiki/reperfusion_therapy#:~:text=Thrombolytic%20therapy%20is%20indicated%20for%20the%20treatment%20of,is%20most%20effective%20in%20the%20first%202%20hours.
https://pubmed.ncbi.nlm.nih.gov/31772517/
Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study. This study is registered with the following: Trial Registration: clinicaltrials.gov; Identifier: NCT02737956. This study is registered with the following: Trial Registration: clinicaltrials.gov; Identifier: …
https://www.medscape.org/viewarticle/506638
June 15, 2005 — Stenting with abciximab can reduce infarct size in acute ST-segment elevation myocardial infarction (STEMI) even in patients presenting more than 12 hours after symptom onset, according to the results of an international, open-label, randomized trial published in the June 15 issue of JAMA.
https://litfl.com/stemi-management/
All patients who present within 12 hours of symptom onset of STEMI should be considered for a reperfusion strategy, unless they have severe co-morbidities. Reperfusion is not routinely recommended in patients who present more than 12 hours after symptom onset. It may be considered however in selected cases when: There are ongoing symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795868/
Among 83 patients with STEMI 50.6% were males and 49.4% were females with the age group range of 30-83 years. Fifty nine patients (71.08%) with STEMI underwent thrombolysis within 12 hours of onset of chest pain while 24 patients (28.92%), underwent thrombolysis after 12 hours of onset of chest pain.
https://jamanetwork.com/journals/jama/fullarticle/201747
The goal of the BRAVE 2 trial was to assess whether an invasive strategy is associated with reduction of infarct size in patients with STEMI presenting more than 12 hours after symptom onset. The study was based on symptoms and unequivocal electrocardiographic changes to define acute MI, and on the interval from symptom onset to define time to …
https://www.healio.com/cardiology/learn-the-heart/cardiology-review/topic-reviews/coronary-artery-disease-stemi/treatment-revascularization
The best outcomes occur when primary PCI is performed with a door-to-balloon time of < 90 minutes and when symptoms onset was < 12 hours.
https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.118.007287
Remarkably, a time threshold to define late presentation (>12 hours) for primary percutaneous coronary intervention (PCI) was inferred from data derived from outcomes with lytic therapies, generating debate as to whether such an approach is appropriate. 6 The LATE study (Late Assessment of Thrombolytic Efficacy) showed no morality benefits in patients …
https://www.cardioguide.ca/thrombolysis-in-stemi/
Patients with chest pain suggestive of acute myocardial ischemia who present up to 12 (possibly up to 24 hours) after symptom onset of symptoms are candidates for reperfusion with fibrinolytic therapy. The magnitude of the reduction in the risk of death in randomized trials is generally between 15 and 30 percent.
https://www.healio.com/cardiology/learn-the-heart/cardiology-review/topic-reviews/coronary-artery-disease-stemi/treatment-medical
Treatment - STEMI Medical Therapy. Initial medical therapy during STEMI consists of oxygen administration, antiplatelet therapy (aspirin, thienopyridines and glycoprotein IIb/IIIa inhibitors ...
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