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https://www.piramalcriticalcare.com/us/wp-content/uploads/sites/2/2018/09/MKT-SEV-054-02-MAR-2018-Sevoflurane-Sell-Sheet091918.pdf#:~:text=To%20minimize%20exposure%20to%20Compound%20A%2C%20sevoflurane%20exposure,gas%20flow%20rates%20%3C1%20L%2Fmin%20are%20not%20recommended.
http://ether.stanford.edu/library/neuroanesthesia/SNACC%20Reading%20List%20articles/Duffy_%20Sevoflurane%20and%20anesthesia.pdf
3 MAC hours of inhalational agent found that emergence time correlated with MAC hours for isoflurane, but not for sevoflurane (25). Ebert et al have evaluated a database of randomized controlled trials comparing recovery end-points for isoflurane and sevoflurane in surgical cases last-ing up to 5 hours. They found that emergence times in-
https://askinglot.com/what-is-the-mac-for-sevoflurane
Anesthetic gas exposures are quantified in MAC-hours, defined as an exposure at 1 times the minimum alveolar concentration that prevents movement with a noxious stimulus in 50% of subjects (MAC) for 1 hour (2).
https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020478s016lbl.pdf
clinical study in which sevoflurane was administered to patients under low flow conditions for ≥ 2 hours at flow rates of 1 Liter/minute, Compound A levels were measured in an effort to determine...
https://journals.lww.com/anesthesia-analgesia/Fulltext/2002/11000/Sevoflurane_Provides_Faster_Recovery_and.52.aspx
Studies involving anesthetic exposure of approximately 1.0 MAC-hours show a time to emergence of 8 minutes with SEVO (5), whereas we obtained 15 minutes, a twofold difference. Frink et al. (9), in a study involving 2.5 MAC-hours of exposure, obtained a time to emergence of 7.5 minutes with SEVO.
https://pubs.asahq.org/anesthesiology/article/82/1/38/34901/Clinical-Characteristics-of-Sevoflurane-in
,* It has been suggested that sevoflurane exposures up to 15 MAC-hours in adults are safe.* Although the risk of sevoflurane toxicity in children remains unknown, the evidence indicates that children may metabolize inhalational anesthetics less than do adults.
https://journals.lww.com/anesthesia-analgesia/Fulltext/1995/12001/Sevoflurane_and_Renal_Function.6.aspx
Frink et al. administered sevoflurane to 50 surgical patients for an average of 3.6 MAC-hours (range, 1.0-7.0 MAC-hours). The mean peak plasma fluoride concentration observed was 29.3 +/- 1.8 micro Meter.
https://www.researchgate.net/publication/315624220_EFFECT_OF_LONG_DURATION_SEVOFLURANE_ANESTHESIA_ON_LIVER_FUNCTION
duration (>5 hours) lo w flow (1L/min) sevoflurane anesthesia on human renal and hepatic function. Assessment of changes in hepatic function was done by
https://www.anesthesiologyhub.com/content/dam/acp-hub/global/documents/ultane/Ultane_Dosing_Flow_Chart.pdf
Anesthesia Time Guidelines at 1 L fresh gas flow rate/min1. 2. MAC– hours. ULTANE exposure should not exceed 2 MAC-hours at flow rates of 1 to <2 L/min. Fresh gas flow rates <1 L/min are not recommended. There is a potential for renal injury when ULTANE is used at low flow rates. Important Safety Information1.
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