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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278801/
Dec 28, 2013 · Developing a systemic gene delivery system that is tumor specific involves choosing a basic delivery method and then overcoming the natural tropism of that system in order to achieve tumor specificity. Once tumor specificity is realized, a therapeutic gene must be chosen that will maximize treatment potential.Author: Max Kullberg, Ryan McCarthy, Thomas J. Anchordoquy
https://www.ncbi.nlm.nih.gov/pubmed/24035974
Dec 28, 2013 · Systemic tumor-specific gene delivery. Kullberg M(1), McCarthy R, Anchordoquy TJ. Author information: (1)Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, 12850 Montview Boulevard, Aurora, Colorado 80045, USA. Electronic address: [email protected]: Max Kullberg, Ryan McCarthy, Thomas J. Anchordoquy
https://www.sciencedirect.com/science/article/pii/S016836591300789X
Developing a systemic gene delivery system that is tumor specific involves choosing a basic delivery method and then overcoming the natural tropism of that system in order to achieve tumor specificity. Once tumor specificity is realized, a therapeutic gene must be …Author: Max Kullberg, Ryan McCarthy, Thomas J. Anchordoquy
https://www.researchgate.net/publication/256610593_Systemic_Tumor-Specific_Gene_Delivery
Systemic Tumor-Specific Gene Delivery. ... delivery systems in order to determine the techniques that are most effective in achieving tumor specific gene expression after systemic administration. ...
https://www.sciencedirect.com/science/article/abs/pii/S016836591300789X
This review analyzes these techniques applied to liposomal, PEI, dendrimer, stem cell and viral gene delivery systems in order to determine the techniques that are most effective in achieving tumor specific gene expression after systemic administration.Author: Max Kullberg, Ryan McCarthy, Thomas J. Anchordoquy
http://www.nature.com/articles/3302843
Aug 17, 2006 · Hatakeyama, H., Akita, H., Kogure, K. et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.Author: H Hatakeyama, H Akita, K Kogure, M Oishi, Y Nagasaki, Y Kihira, M Ueno, H Kobayashi, H Kikuchi, H Ha...
https://academic.oup.com/jnci/article/91/20/1744/2543860
Oct 20, 1999 · An ideal tumor-directed gene therapy vector should demonstrate tumor-specific expression of a foreign gene after systemic application. Vaccinia viruses have the ability to carry large amounts of foreign DNA (up to 25 kilobases) and have high intrinsic transduction efficiency; both of these attributes make these viruses promising candidates for gene therapy ( 1).Author: Michael F. X. Gnant, Linda A. Noll, Kari R. Irvine, Markus Puhlmann, Richard E. Terrill, H. Richard ...
https://mct.aacrjournals.org/content/1/5/337
Mar 01, 2002 · Systemic Tumor-targeted Gene Delivery by Anti-Transferrin Receptor scFv-Immunoliposomes 1 This work was supported in part by National Cancer Institute Grant R01 CA45158 (to E. C.), National Cancer Institute Small Business Technology Transfer Phase I Grant R41 CA80449 (to E. C.), and a grant from SynerGene Therapeutics, Inc.1Author: Liang Xu, Cheng-Cheng Huang, Weiqun Huang, Wen-Hua Tang, Antonina Rait, Yu Zhi Yin, Idalia Cruz, Lai...
https://www.nature.com/articles/3300468
Aug 01, 1997 · A fundamental obstacle in gene therapy for cancer treatment is the specific delivery of an anticancer gene product to a solid tumor. Although several strategies exist to control gene …Author: MJ Lemmon, P van Zijl, ME Fox, ML Mauchline, AJ Giaccia, NP Minton, JM Brown
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fba.1026
and tumor‐specific gene delivery vectors remains an issue. Tumor responsive cell‐ penetrating peptide (CPP) PepFect144 (PF144) has previously been shown to deliver reporter gene encoding plasmid DNA specifically into tumors upon systemic admin-istration, but its capability to reduce tumor growth has not yet been evaluated. Here,Author: Kadri Künnapuu, Kadi‐Liis Veiman, Ly Porosk, Evelin Rammul, Kristina Kiisholts, Ülo Langel, Ülo Lang...
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