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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129804/
Mar 22, 2011 · Systemic delivery of let-7 or miR-34 inhibits tumor growth in the K-ras autochthonous NSCLC mouse model. We have previously reported that let-7 and miR-34 interfere with tumor growth in mouse models of NSCLC. 19,20,27 However, the therapeutic effects of systemic delivery of their respective miRNA mimics in an orthotopic tumor model has not yet been investigated.Author: Phong Trang, Jason F Wiggins, Christopher L Daige, Chris Cho, Michael Omotola, David Brown, Joanne B...
https://www.ncbi.nlm.nih.gov/pubmed/21427705
Therapeutic delivery was demonstrated using mimics of the tumor suppressors, microRNA-34a (miR-34a) and let-7, both of which are often down regulated or lost in lung cancer. Systemic treatment of a Kras-activated autochthonous mouse model of non-small cell lung cancer (NSCLC) led to a significant decrease in tumor burden.Author: Phong Trang, Jason F Wiggins, Christopher L Daige, Chris Cho, Michael Omotola, David Brown, Joanne B...
https://www.sciencedirect.com/science/article/pii/S1525001616319165
Systemic delivery of let-7 or miR-34 inhibits tumor growth in the K-ras autochthonous NSCLC mouse model. We have previously reported that let-7 and miR-34 interfere with tumor growth in mouse models of NSCLC. 19, 20, 27 However, the therapeutic effects of systemic delivery of their respective miRNA mimics in an orthotopic tumor model has not yet been investigated.Author: Phong Trang, Jason F Wiggins, Christopher L Daige, Chris Cho, Michael Omotola, David Brown, Joanne B...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31916-5
Jun 01, 2011 · Therapeutic delivery was demonstrated using mimics of the tumor suppressors, microRNA-34a (miR-34a) and let-7, both of which are often down regulated or lost in lung cancer. Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice: Molecular TherapyAuthor: Phong Trang, Jason F Wiggins, Christopher L Daige, Chris Cho, Michael Omotola, David Brown, Joanne B...
https://www.researchgate.net/publication/50808750_Systemic_Delivery_of_Tumor_Suppressor_microRNA_Mimics_Using_a_Neutral_Lipid_Emulsion_Inhibits_Lung_Tumors_in_Mice
Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice Article (PDF Available) in Molecular Therapy 19(6):1116-22 · March 2011 with 347 ...
https://www.sciencedirect.com/science/article/pii/S0168365919306492
Therefore, systemic delivery of AMO-21 may be a useful approach for glioblastoma gene therapy. With the purpose of developing the effects of AMO-21 by systemic administration, T7-exo seemed to be an adequate delivery carrier compared with RVG-exo because it can …Author: Gyeungyun Kim, Minkyung Kim, Youngki Lee, Jung Woo Byun, Do Won Hwang, Minhyung Lee
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)31916-5.pdf
a tumor suppressor by regulating multiple cell cycle and cell sur-vival genes.11–13 miR-34 is directly transcribed by the p53 tumor suppressor gene and is required for a radiation response in vitro and in vivo.14,15 Delivery of endogenous tumor suppressor miRNAs as syn-thetic miRNA mimics has emerged as a promising approach to
https://www.mdpi.com/2073-4409/9/2/521/htm
Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with …Author: Clodagh P. O’Neill, Róisín M. Dwyer
https://cancerres.aacrjournals.org/content/70/14/5923
Jul 15, 2010 · The data provide proof of concept for the systemic delivery of a synthetic tumor suppressor mimic, obviating obstacles associated with viral-based miRNA delivery and facilitating a rapid route for miRNA replacement therapy into the clinic. Cancer Res; 70(14); 5923–30. ©2010 AACR.Author: Jason F. Wiggins, Lynnsie Ruffino, Kevin Kelnar, Michael Omotola, Lubna Patrawala, David Brown, Andr...
https://www.nature.com/articles/s41551-018-0284-0
Sep 17, 2018 · Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a well-characterized tumour-suppressor gene that is lost or mutated in about half of metastatic castration-resistant prostate ...Author: Mohammad Ariful Islam, Yingjie Xu, Wei Tao, Jessalyn M. Ubellacker, Jessalyn M. Ubellacker, Michael ...
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