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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Systemic Delivery. The site of action of siRNA therapeutics is the cytosol. The barriers to siRNA delivery are multiple and depend on the targeted organs and the administration routes. In general, locoregional delivery of siRNA has fewer barriers compared to systemic delivery.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348392/
May 10, 2012 · Systemic delivery of siRNA to solid tumors remains challenging. In this study, we investigated the systemic delivery of an siRNA-nanoparticle targeting ribonucleotide reductase subunit M2 (RRM2), and evaluated its intratumoral kinetics, efficacy and mechanism of action.Author: Mohammad Aminur Rahman, A. R M Ruhul Amin, Xu Wang, Jonathan E. Zuckerman, Chung Hang J Choi, Bingse...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172140/
Jul 25, 2009 · Lipid-based drug delivery system has been widely accepted in the clinic, especially in chemotherapy, for more than two decades. Now, lipid-based delivery system also works promisingly and safely in systemic siRNA delivery. Although the recent success is encouraging, there still remains much room for improvement.Author: Yu Cheng Tseng, Subho Mozumdar, Subho Mozumdar, Leaf Huang
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201709485
Oct 26, 2017 · The siRNA delivered by the DNPs inhibited cell growth both in vitro and in vivo, which suppressed tumor growth in a xenograft model that specifically correlated with Bcl2 depletion. This study suggests that DNPs are effective tools for the systemic delivery of therapeutic siRNA and have great potential for further clinical translation.Author: Mohammad Aminur Rahman, Pengfei Wang, Zhixiang Zhao, Zhixiang Zhao, Dongsheng Wang, Sreenivas Nannap...
https://pubs.rsc.org/en/content/articlelanding/2019/bm/c9bm00369j
Systemic delivery of small interfering RNA (siRNA) has been mainly impeded by enzymatic degradation and poor cellular uptake. Calcium phosphate (CaP) has been considered a potential candidate for siRNA delivery because of its excellent biocompatibility and capability of entrapping siRNA in the crystal core.Author: Yue Yin, Min Sang Lee, Jung Eun Lee, Su Yeon Lim, E Seul Kim, Jaeback Jeong, Dahwun Kim, Jaeyun Kim,...
https://www.sciencedirect.com/science/article/pii/S0168365911005621
Dec 10, 2011 · Systemic delivery of specific siRNA by nanoparticles significantly inhibited luciferase expression in an orthotopic murine liver cancer model and suppressed tumor growth in a MDA-MB-435s murine xenograft model, suggesting its therapeutic promise in disease treatment.Author: Xian-Zhu Yang, Shuang Dou, Tian-Meng Sun, Cheng-Qiong Mao, Hong-Xia Wang, Jun Wang
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