Systemic Delivery Of Sirna With Cationic Lipid

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Systemic delivery of siRNA with cationic lipid assisted ...

    https://www.sciencedirect.com/science/article/pii/S0168365911005621
    Dec 10, 2011 · Here, we describe a cationic lipid assisted polymeric nanoparticle system with stealthy property for efficient siRNA encapsulation and delivery, which was fabricated with poly (ethylene glycol)- b -poly ( d,l -lactide), siRNA and a cationic lipid, using a double emulsion-solvent evaporation technique.Author: Xian-Zhu Yang, Shuang Dou, Tian-Meng Sun, Cheng-Qiong Mao, Hong-Xia Wang, Jun Wang

Systemic delivery of siRNA with cationic lipid assisted ...

    https://www.sciencedirect.com/science/article/abs/pii/S0168365911005621
    Polymeric nanoparticle system fabricated with poly(ethylene glycol)- b -poly(d,l -lactide), siRNA under the assistance of a cationic lipid exhibits efficient siRNA encapsulation and effective systemic delivery to cancer cells both in vitro and in vivo. Download : Download full-size image Previous article in issue Next article in issueAuthor: Xian-Zhu Yang, Shuang Dou, Tian-Meng Sun, Cheng-Qiong Mao, Hong-Xia Wang, Jun Wang

Systemic delivery of siRNA with cationic lipid assisted ...

    https://www.researchgate.net/publication/51569036_Systemic_delivery_of_siRNA_with_cationic_lipid_assisted_PEG-PLA_nanoparticles_for_cancer_therapy
    Request PDF Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy Delivery of small interfering RNA (siRNA) has been one …

Lipid-based systemic delivery of siRNA - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172140/
    Jul 25, 2009 · Lipid-based drug delivery system has been widely accepted in the clinic, especially in chemotherapy, for more than two decades. Now, lipid-based delivery system also works promisingly and safely in systemic siRNA delivery. Although the recent success is encouraging, there still remains much room for improvement.Author: Yu Cheng Tseng, Subho Mozumdar, Subho Mozumdar, Leaf Huang

Effect of cationic lipid in cationic liposomes on siRNA ...

    https://www.tandfonline.com/doi/abs/10.1080/1061186X.2018.1502775
    (2019). Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex. Journal of Drug Targeting: Vol. 27, No. 2, pp. 217-227.Author: Yoshiyuki Hattori, Mari Nakamura, Nozomi Takeuchi, Kyoko Tamaki, Satono Shimizu, Yuki Yoshiike, Masa...

Designer Lipids Advance Systemic siRNA Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862526/
    Cationic lipids hold great promise for systemic delivery of siRNA. However, they are not the only solution. The fate of a siRNA formulation in vivo is affected by various factors such as particle size, morphology, and surface chemistry. Sophisticated structures of the particles and preparation methods also influence the in vivo effect considerably. Other formulation strategies, such as attaching a …Author: Yang Liu, Leaf Huang

Lipid-based systemic delivery of siRNA - ResearchGate

    https://www.researchgate.net/publication/24240733_Lipid-based_systemic_delivery_of_siRNA
    Lipid-based systemic delivery of siRNA. ... 5 However, major drawbacks of commonly applied cationic lipids for siRNA delivery, e.g., 1,2-dioleoyl-3-trimethylammonium- propane ...

Facile Hydrophobization of siRNA with Anticancer Drug for ...

    https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.9b00657
    The inherent features of small interfering RNA (siRNA), including a relatively high molecular weight, negative charge, and hydrophilic nature, lead to the widespread use of cationic polymers and lipid-based nanocarriers, which might induce potential cytotoxicity, thus limiting their clinical application. Here, we report a facile strategy for changing the inherent features of siRNA molecules by ...Author: Congfei Xu, Dongdong Li, Zhiting Cao, Menghua Xiong, Xianzhu Yang, Jun Wang

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