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https://www.sciencedirect.com/science/article/pii/S0168365911005621
Dec 10, 2011 · Here, we describe a cationic lipid assisted polymeric nanoparticle system with stealthy property for efficient siRNA encapsulation and delivery, which was fabricated with poly (ethylene glycol)- b -poly ( d,l -lactide), siRNA and a cationic lipid, using a double emulsion-solvent evaporation technique.Author: Xian-Zhu Yang, Shuang Dou, Tian-Meng Sun, Cheng-Qiong Mao, Hong-Xia Wang, Jun Wang
https://www.sciencedirect.com/science/article/abs/pii/S0168365911005621
Polymeric nanoparticle system fabricated with poly(ethylene glycol)- b -poly(d,l -lactide), siRNA under the assistance of a cationic lipid exhibits efficient siRNA encapsulation and effective systemic delivery to cancer cells both in vitro and in vivo. Download : Download full-size image Previous article in issue Next article in issueAuthor: Xian-Zhu Yang, Shuang Dou, Tian-Meng Sun, Cheng-Qiong Mao, Hong-Xia Wang, Jun Wang
https://www.researchgate.net/publication/51569036_Systemic_delivery_of_siRNA_with_cationic_lipid_assisted_PEG-PLA_nanoparticles_for_cancer_therapy
Request PDF Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy Delivery of small interfering RNA (siRNA) has been one …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172140/
Jul 25, 2009 · Lipid-based drug delivery system has been widely accepted in the clinic, especially in chemotherapy, for more than two decades. Now, lipid-based delivery system also works promisingly and safely in systemic siRNA delivery. Although the recent success is encouraging, there still remains much room for improvement.Author: Yu Cheng Tseng, Subho Mozumdar, Subho Mozumdar, Leaf Huang
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2018.1502775
(2019). Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex. Journal of Drug Targeting: Vol. 27, No. 2, pp. 217-227.Author: Yoshiyuki Hattori, Mari Nakamura, Nozomi Takeuchi, Kyoko Tamaki, Satono Shimizu, Yuki Yoshiike, Masa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862526/
Cationic lipids hold great promise for systemic delivery of siRNA. However, they are not the only solution. The fate of a siRNA formulation in vivo is affected by various factors such as particle size, morphology, and surface chemistry. Sophisticated structures of the particles and preparation methods also influence the in vivo effect considerably. Other formulation strategies, such as attaching a …Author: Yang Liu, Leaf Huang
https://www.researchgate.net/publication/24240733_Lipid-based_systemic_delivery_of_siRNA
Lipid-based systemic delivery of siRNA. ... 5 However, major drawbacks of commonly applied cationic lipids for siRNA delivery, e.g., 1,2-dioleoyl-3-trimethylammonium- propane ...
https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.9b00657
The inherent features of small interfering RNA (siRNA), including a relatively high molecular weight, negative charge, and hydrophilic nature, lead to the widespread use of cationic polymers and lipid-based nanocarriers, which might induce potential cytotoxicity, thus limiting their clinical application. Here, we report a facile strategy for changing the inherent features of siRNA molecules by ...Author: Congfei Xu, Dongdong Li, Zhiting Cao, Menghua Xiong, Xianzhu Yang, Jun Wang
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