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https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(01)90386-7
May 01, 2001 · The necessity of more efficient synthetic gene delivery methods prompted us to search for novel, non-or less cationic, gene delivery systems. Such systems would thus not be based solely on electrostatic interactions with DNA. These non-electrostatic complexes could be advantageous for in vitro and in vivo applications, since unlike cationic ...
http://spies.olemiss.edu/genedelivery/
Synthetic Gene Delivery Vehicles The delivery of intravenous nucleic acid therapies is hampered by the rapid degradation of naked nucleic acids by enzymes found in blood. The use of a delivery vehicle to protect therapeutic nucleic acids greatly improves the nuclease resistance and circulation thus prolonging the therapeutic effect in vivo.
https://www.nature.com/articles/s41570-018-0039-1
Sep 21, 2018 · The delivery of nucleic acids with transient activity for genetic engineering is a promising methodology with potential applications in the treatment of …Author: Irene Lostalé-Seijo, Javier Montenegro
https://www.nature.com/articles/nbt0100_33
Jan 01, 2000 · Current synthetic DNA delivery systems are versatile and safe, but substantially less efficient than viruses. Indeed, most current systems address only one of the obstacles to DNA delivery …Author: Dan Luo, W. M. Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227300/
Synthetic virology aims to engineer viruses for gene delivery through the incorporation of natural or synthetic parts. Multiple facets of viruses may need to be enhanced or altered in order to become effective delivery agents for gene therapy applications.Author: Caitlin M. Guenther, Brianna E. Kuypers, Michael T. Lam, Tawana M. Robinson, Julia Zhao, Junghae Suh
https://pubs.acs.org/doi/abs/10.1021/jm500330k
Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene delivery and gene silencing, in which scientists are designing novel cationic and procationic amphiphiles that can pack, transport, and deliver nucleic acids to various targets in the body in a controlled manner.Author: Bogdan Draghici, Marc A. Ilies
https://www.genscript.com/gene_synthesis.html
Compared to traditional molecular cloning techniques, GenScript's gene synthesis service saves both time and money while offering unparalleled top to bottom customizability. Up to date, the success rate and the on-time delivery rate of gene synthesis has achieved 99.95% and 98.5%, respectively.
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
A synthetic gene delivery system: [1] should protect the negatively-charged phosphate DNA skeleton against anionic cell surface from load repulsion, [2] should be condensed to suitable length intervals of DNA with a macromolecular structure for cellular internalization (condensing at nanometer size for receptor compatible endocytosis or condensing at micrometer size for phagocytosis); and [3] should …Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
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