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https://link.springer.com/chapter/10.1007/978-1-4614-0881-9_7
Sep 27, 2011 · Swelling Controlled Drug Delivery Systems. Abstract. This chapter provides an introduction to the physical phenomena, which can be involved in the control of drug release from swellable delivery systems, namely, water diffusion, polymer chain relaxation, drug dissolution and diffusion, as well as polymer dissolution.Author: Juergen Siepmann, Florence Siepmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305323/
Metformin is a freely water-soluble drug; therefore, the rate-determining step in the drug release was the swelling rate of the matrix. Therefore, the length and resistance of the diffusion paths determined the release profiles of metformin in media containing different NaCl amounts.Author: Ying Chen Chen, Hsiu O. Ho, Der Zen Liu, Der Zen Liu, Wen Shian Siow, Ming Thau Sheu, Ming Thau Sheu
https://www.sciencedirect.com/science/article/pii/0142961288900439
Swelling-activated drug delivery systems. Abstract. A previous paper dealt with the preparation of an in vitro programmable zero-order drug delivery system in which the area of the surface exposed to the dissolution medium and the macromolecular relaxation of polymer controlled the release of the drug.Author: U. Conte, P. Colombo, A. Gazzaniga, M.E. Sangalli, A. La Manna
https://www.researchgate.net/publication/278650509_Swelling_Controlled_Drug_Delivery_Systems
Another example is the cross-linked gelatin that has the ability to act as a swelling-controlled drug release system such as in gelatin B emulsion cross-linked by genipin, which forms small-sized ...
https://www.intechopen.com/books/smart-drug-delivery-system/swellable-hydrogel-based-systems-for-controlled-drug-delivery
1.3. Phenomenology of drug release from swelling hydrogels. In controlled drug delivery, the main goal is to design systems able to give tailored release profiles, as function of the time as well as in response to external stimuli (sensitive systems) and/or in a certain environment (targeted delivery systems).Author: Diego Caccavo, Sara Cascone, Gaetano Lamberti, Anna Angela Barba, Anette Larsson
https://www.mddionline.com/polymers-controlled-drug-delivery
There are three primary mechanisms by which active agents can be released from a delivery system: diffusion, degradation, and swelling followed by diffusion. Any or all of these mechanisms may occur in a given release system. Diffusion occurs when a drug or other active agent passes through the polymer that forms the controlled-release device.
https://pdfs.semanticscholar.org/d4bf/601ff73039ee8cdbe0130559bd868395dd05.pdf
Approaches include floating drug delivery systems (FDDS), also known as Hydro dynamically balanced systems (HBS), Swelling & expanding systems, High-density systems, and other Delayed gastric emptying devices. Floating dosage form can be prepared
http://ijpsr.com/bft-article/floating-drug-delivery-system-a-review-2/?view=fulltext
Sustained Release Drug Delivery System: HBS systems can remain in the stomach for longperiods and, hence can release the drug over aprolonged period of time. The problem of shortgastric residence time encountered with an oral CRformulation hence can be overcome with these systems.
https://www.sciencedirect.com/science/article/pii/B9780081000922000060
Unlimited swelling matrices display diffusion as the main mechanism of drug release control. On the other hand, considering hydrophilic matrices with limited swelling, the mechanism of drug release control is the velocity of the dissolution medium (penetrant).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898614/
The clinical use of drug delivery systems is appreciable 7, with a global market of over $150 US billion in 2013. Hydrogels are a particularly appealing type of drug delivery system, and have been used in many branches of medicine, including cardiology, oncology, immunology, wound …Author: Jianyu Li, David J. Mooney
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