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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306122/
Dec 26, 2010 · To overcome the above mentione d limitations, an increasing number of sustained-release drug delivery devices using different mechanisms and containing a variety of agents have been developed to treat uveitis. This article reviews major drug delivery technologies currently in clinical trials or at experimental stages for treatment of uveitis.Author: Nahid Haghjou, Masoud Soheilian, Mohammad Jafar Abdekhodaie
https://medical-dictionary.thefreedictionary.com/Surodex
Surodex: Ophthalmology A controlled-release, intraocular drug-delivery system containing dexamethasone instilled into the anterior chamber of the eye during cataract surgery to ↓ pain and swelling postoperatively
https://www.changcataract.com/websites/os021598.htm
Surodex (dexamethasone, Oculex Pharmaceuticals) may be an example of just such a product. Oculex Pharmaceuticals is a Silicon Valley biotechnology firm that was cofounded by an academic ophthalmologist from Georgetown, Dr. Vernon Wong. Oculex has developed a sustained release, intraocular drug delivery system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1771875/
Surodex significantly reduces the total dose delivered, as the 60 μg of dexamethasone in one pellet is approximately equivalent to that in just one drop of 0.1% dexamethasone. 10 A system such as the DDS allows for direct application of the drug to the target site, potentially eliminating the problems of …Author: S-Y Lee, S-P Chee, V Balakrishnan, S Farzavandi, D T H Tan
https://www.sciencedirect.com/science/article/pii/S0161642001008399
This study represents our second human clinical trial using the Surodex Drug Delivery System to deliver a controlled intraocular dosage of dexamethasone after cataract extraction and confirms that, as in the first trial, placement of Surodex results in significant reduction in aqueous flare.Author: Donald T.H. Tan, Soon-Phaik Chee, Li Lim, Julian Theng, Manon Van Ede
https://link.springer.com/article/10.1007/s00417-003-0753-2
Sep 04, 2003 · To investigate the effects of a new biodegradable dexamethasone drug delivery system, Surodex, in two experimental intraocular inflammation models; endotoxin-induced uveitis (EIU) and experimental autoimmune uveoretinitis (EAU). Surodex was inserted into the …Author: Masuhiro Kodama, Jiro Numaga, Jiro Numaga, Atsushi Yoshida, Toshikatsu Kaburaki, Tetsuro Oshika, Yuj...
https://www.sciencedirect.com/science/article/abs/pii/S0886335003009209
The Surodex group had the dexamethasone drug delivery system inserted into the anterior chamber (AC) angle during surgery and was treated with saline eyedrops (Isopto Plain ®) for 4 weeks. The control group had no drug delivery system or a placebo inserted at surgery and were treated with dexamethasone 0.1% eyedrops for 4 weeks.Author: Azfar C Wadood, Ana M Armbrecht, Peter A Aspinall, Baljean Dhillon
https://www.hindawi.com/journals/mi/2013/780634/
A randomized clinical trial of Surodex as a steroid drug delivery system for cataract surgery showed the implant to be safe and effective in reducing postoperative inflammation. Their study included a group of subjects receiving two pellets in the anterior chamber, two pellets in the ciliary sulcus, and a control group that only received ...Author: Jillian Wang, Angela Jiang, Malav Joshi, John B Christoforidis
https://www.aao.org/eyenet/article/promise-of-implantable-drug-delivery-systems
Combination drug delivery system also hold appeal, especially for inflammatory diseases. Coad-ministering drugs may mitigate complications for example, by perhaps minimizing the effects of an anti-VEGF with a neuroprotectant. The drug that delivers itself.
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
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