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https://link.springer.com/article/10.1007%2Fs10544-005-3024-7
We designed and fabricated an array of sugar micro needles of the length ranging from 150 μ m to 2 mm for transdermic delivery of drugs. Micro needles were molded out of maltose mixed with pharmaceutical material, being expected bio-degradable in the human skin.Author: Takaya Miyano, Yoshikazu Tobinaga, Takahiro Kanno, Yasushi Matsuzaki, Hitoshi Takeda, Makoto Wakui, ...
https://www.researchgate.net/publication/7626943_Sugar_Micro_Needles_as_Transdermic_Drug_Delivery_System
We designed and fabricated an array of sugar micro needles of the length ranging from 150 micro m to 2 mm for transdermic delivery of drugs. Micro needles were molded out of maltose mixed with ...
http://europepmc.org/abstract/MED/16133805
Oct 01, 2005 · We designed and fabricated an array of sugar micro needles of the length ranging from 150 micro m to 2 mm for transdermic delivery of drugs. Micro needles were molded out of maltose mixed with pharmaceutical material, being expected bio-degradable in the human skin.Author: Takaya Miyano, Yoshikazu Tobinaga, Takahiro Kanno, Yasushi Matsuzaki, Hitoshi Takeda, Makoto Wakui, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917494/
Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here, we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin’s antigen-presenting cells.Author: Sean P Sullivan, Dimitrios G Koutsonanos, Maria del Pilar Martin, Jeong Woo Lee, Vladimir Zarnitsyn,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310406/
Mar 12, 2012 · Introduction. Microneedle technology has been developing as a drug-delivery system for more than a decade.1 The principal advantage of microneedles is that they can provide a minimally invasive means of transporting molecules into the skin.2 This is particularly true for protein and peptide drugs, which are mostly administered by frequent injections due to their large molecular weight, short ...Author: Sixing Yang, Yan Feng, Lijun Zhang, Nixiang Chen, Weien Yuan, Tuo Jin
https://www.sciencedirect.com/science/article/pii/S0753332218348091
Combination of ultrasound and transdermal drug delivery is also studied in order to further increase the drug permeability . Thus, microneedles can be fabricated with a variety of modifications in order to smartly deliver the drug through the skin providing a new direction and revolution in the field of transdermal drug delivery systems.Author: Tejashree Waghule, Gautam Singhvi, Sunil Kumar Dubey, Murali Monohar Pandey, Gaurav Gupta, Mahaveer ...
https://link.springer.com/article/10.1007%2Fs11095-006-0028-9
May 04, 2006 · As an alternative to hypodermic injection or implantation of controlled-release systems, this study designed and evaluated biodegradable polymer microneedles that encapsulate drug for controlled release in skin and are suitable for self-administration by patients. Arrays of microneedles were fabricated out of poly-lactide-co-glycolide using a mold-based technique to encapsulate model drugs ...Author: Jung-Hwan Park, Mark G. Allen, Mark R. Prausnitz
https://www.nature.com/articles/nm.2182
Jul 18, 2010 · Sullivan and his colleagues describe a novel microneedle patch-based system for vaccine delivery that targets the skin's antigen-presenting cells, providing improved immunogenicity and …Author: Sean P Sullivan, Dimitrios G Koutsonanos, Maria del Pilar Martin, Jeong Woo Lee, Vladimir Zarnitsyn,...
https://www.cambridge.org/core/journals/robotica/article/3d-manipulation-of-an-active-steerable-needle-via-actuation-of-multiple-sma-wires/7A9244A39E764563F361234C6C4484E1
Many medical procedures such as brachytherapy, thermal ablations, and biopsies are performed using needle-based procedures. In this work, 3D manipulation of an active needle realized by multiple Shape Memory Alloy (SMA) actuators was first predicted by Finite Element Analyses (FEA), and then demonstrated by a fabricate prototype.Author: Bardia Konh, Dayne Sasaki, Tarun K. Podder, Hashem Ashrafiuon
https://www.semanticscholar.org/paper/Hydrolyticmicroneedles-as-Transdermal-Drug-Delivery-Miyano-Miyachi/93fbe10941dad2cd399f75a5f4bd58e52fa6f4cb
We developed hydrolytic microneedles as a transdermal drug delivery system to overcome the shortcomings of existing microneedle-systems: long-term stay of broken needles in the skin and high cost for safe disposal of used needles. The present microneedles spontaneously dissolve by hydrolysis in human skin as well as in the (boiled) water. We verified their basic utility through experiments.
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