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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765786/
Oct 12, 2009 · Gene transfer from the surface of a biomaterial, termed reverse transfection 1, solid-phase delivery 2, or substrate-mediated delivery 3 immobilizes DNA vectors onto a surface as opposed to more typical bolus delivery from the media.Author: Jennifer C. Rea, Jennifer C. Rea, Romie F. Gibly, Nicolynn E. Davis, Annelise E. Barron, Lonnie D. S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752203/
1. Introduction. Biomaterials have been used for many therapeutic and research applications such as tissue engineering and gene delivery. Gene transfer from the surface of a biomaterial, termed reverse transfection [], solid-phase delivery [] or substrate-mediated delivery [], immobilizes DNA vectors onto a surface as opposed to more typical bolus delivery from the media.Author: Jennifer C. Rea, Romie F. Gibly, Annelise E. Barron, Lonnie D. Shea
https://pubs.acs.org/doi/full/10.1021/am303029k
Substrate-mediated transfection is one of the key strategies for localized gene delivery. Layer-by-layer (LbL) polyelectrolyte deposition is a promising technique which enables controlled delivery of a number of biofactors, including nucleic acids. Here, we embed lipoplexes containing plasmid DNA within polyelectrolyte multilayers composed of glycol-chitosan (Glyc-CHI) and hyaluronic acid (HA ...Author: Christina A. Holmes, Maryam Tabrizian
https://www.sciencedirect.com/science/article/pii/S1742706108003188
1. Introduction. Biomaterials have been used for many therapeutic and research applications such as tissue engineering and gene delivery. Gene transfer from the surface of a biomaterial, termed reverse transfection , solid-phase delivery or substrate-mediated delivery , immobilizes DNA vectors onto a surface as opposed to more typical bolus delivery from the media.Author: Jennifer C. Rea, Romie F. Gibly, Annelise E. Barron, Lonnie D. Shea
https://www.researchgate.net/publication/23457819_Self-assembling_peptide-lipoplexes_for_substrate-mediated_gene_delivery
Substrate-mediated gene delivery (SMD), also known as reverse transfection or solidphase delivery, is a method of immobilizing DNA complexes to the substrate via covalent attachment or nonspecific ...
https://www.sciencedirect.com/science/article/pii/S0927776516305653
Substrate-mediated delivery of functional plasmid DNA (pDNA) has been proven to be a promising strategy to promote competitiveness of endothelial cells (ECs) over smooth muscle cells (SMCs), which is beneficial to inducing fast endothelialization of implanted vascular devices.Author: Bo-chao Li, Hao Chang, Ke-feng Ren, Jian Ji
https://www.researchgate.net/publication/26832393_Engineering_Surfaces_for_Substrate-Mediated_Gene_Delivery_Using_Recombinant_Proteins
Substrate mediated gene delivery (SMD) is a method of immobilizing DNA complexes to a substrate via covalent attachment or nonspecific adsorption, which allows for increased transgene expression ...
https://www.frontiersin.org/articles/10.3389/fchem.2019.00051/full
Substrate mediated gene delivery (SMD) is a method of immobilizing DNA complexes to a substrate via covalent attachment or nonspecific adsorption, which allows for increased transgene expression with less DNA compared to traditional bolus delivery. It may also increase cells receptivity to transfection via cell-material interactions.Author: Amy Mantz, Alice Rosenthal, Eric Farris, Tyler Kozisek, Eva Bittrich, Saghar Nazari, Eva Schubert, M...
https://link.springer.com/book/10.1007/978-1-4939-3718-9
The chapters in this book are organized into three major parts: Part I is a section on conventional bolus gene delivery vectors that introduces typical transfection approaches relying on the addition of transfectants to the cell culture medium where the cells are grown in; Part II covers stimuli-responsive bolus transfectants and topics on gene ...Location: Milan
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(10)00201-5
Mar 01, 2011 · Substrate-mediated gene delivery is an actively advancing area of research. For some applications, control over spatial distribution of vehicles and temporal release of vehicles might be necessary to achieve optimal performance. In addition, the ability to achieve this level of control with multiple populations of delivery vehicles is also ...Author: Chung Huei K Wang, Suzie H. Pun
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