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https://www.nature.com/articles/nrd2897
Jan 01, 2010 · Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to ...Author: Lawrence Rajendran, Hans-Joachim Knölker, Kai Simons
https://www.researchgate.net/publication/281693728_Subcellular_targeting_strategies_for_drug_design_and_delivery
Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to ...
https://www.researchgate.net/profile/Kai_Simons/publication/40819980_Rajendran_L_Knlker_HJ_and_Simons_K_Subcellular_targeting_strategies_for_drug_design_and_delivery_Nat_Rev_Drug_Discov_9_29-42/links/0046352a6fa85ec70f000000/Rajendran-L-Knlker-HJ-and-Simons-K-Subcellular-targeting-strategies-for-drug-design-and-delivery-Nat-Rev-Drug-Discov-9-29-42.pdf
current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell
https://www.ncbi.nlm.nih.gov/pubmed/28862054
Lysosomes are of particular interest for the design and delivery of pH-dependent pro-drugs, enhancing selectivity and developing strategies to inhibit drug degradation inside the cells. There is great potential to bring intracellular drug delivery and distribution using nanotherapeutic approaches to target lysosomes for therapeutic interventions.Author: Ankur Sharma, Kalpesh Vaghasiya, Eupa Ray, Rahul Kumar Verma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836276/
Nanoparticle (NP)-mediated drug delivery (NMDD) for active targeting of diseases is a primary goal of nanomedicine. NPs have much to offer in overcoming the limitations of traditional drug delivery approaches, including off-target drug toxicity and the need for the administration of repetitive doses.Author: Okhil K. Nag, James B. Delehanty
https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_2569351
Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design.Author: Lawrence Rajendran, Hans-Joachim Knölker, Kai Simons
https://www.sciencedirect.com/science/article/pii/B9780128136652000016
1.2.2. Drug Targeting Strategies 1.2.2.1. Common approaches of targeted drug delivery. Targeted drug delivery is the ability of the drug to accumulate in the target tissue or organ selectively and quantitatively, independent of the site and methods of administrations.Author: Imane Himri, Abdelkarim Guaadaoui
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2017.1374390
Sep 21, 2017 · AbstractLysosomes are of particular interest for the design and delivery of pH-dependent pro-drugs, enhancing selectivity and developing strategies to inhibit drug degradation inside the cells. There is great potential to bring intracellular drug delivery and distribution using nanotherapeutic approaches to target lysosomes for therapeutic interventions.Author: Ankur Sharma, Kalpesh Vaghasiya, Eupa Ray, Rahul Kumar Verma
https://www.sciencedirect.com/science/article/pii/S0165614712000181
Lipid conjugation of drugs for membrane targeting and subcellular delivery. An important concept in drug design is to ensure that the drug will reach its desired target. However, if this target is within an intracellular compartment or organelle this procedure becomes more complicated.Author: Lawrence Rajendran, Vinod Udayar, Zoë V. Goodger
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(12)00018-1
Bioavailability is a quantitative measure of the capacity of a drug to reach systemic circulation. However, if a drug target is localized in a subcellular organelle, then the drug may not be able to reach it and the effect of the drug will not be attained. Although most drug targets are localized within intracellular compartments, specific targeting of drugs at the subcellular level is not ...Author: Lawrence Rajendran, Vinod Udayar, Zoë V. Goodger
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