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https://www.researchgate.net/publication/6524067_Study_on_a_Nanoparticle_System_for_Buccal_Delivery_of_Insulin
In this paper, a nanoparticle system of insulin (NSI) was prepared for buccal transmucosal delivery of insulin. The average size of the suspending particles was 67.5 nm, and a possible ...
https://www.ncbi.nlm.nih.gov/pubmed/17281326
In this paper, a nanoparticle system of insulin (NSI) was prepared for buccal transmucosal delivery of insulin. The average size of the suspending particles was 67.5 nm, and a possible microstructure of the nanoparticles in the system was proposed.Author: Yong Luo, Huibi Xu, Kaixun Huang, Zhonghong Gao, Hong Peng, Xiqun Sheng
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619439/
Oct 24, 2015 · At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system. This next generation efficient therapy for T1DM may help to improve the quality of life of diabetic patients who routinely employ insulin by the subcutaneous route.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://www.sciencedirect.com/science/article/pii/S0168365917308283
Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment. ... In this study, an insulin-phospholipid complex was prepared by an anhydrous co-solvent lyophilisation procedure. ... A two-stage PLGA/Eudragit® RS nanoparticle delivery system coated with HPMCP-55 further improved the enzymatic protection of insulin ...Author: Chun Y. Wong, Hani Al-Salami, Crispin R. Dass
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/nanoparticle-insulin-drug-delivery-applications-and-new-aspects
Insulin is a key player in lowering blood glucose levels for type 1 diabetes and also required at later stages in type 2 diabetes patients. The widely accepted route for delivery of insulin is by parenteral administration but this delivery of insulin usually requires at least three or four daily insulin injections for good glycemic control.Author: Hatice Kübra Elçioğlu, Ali Demir Sezer
https://www.sciencedirect.com/science/article/pii/S0168365920300146
In a different study, a delivery system was developed to increase the buccal permeability for therapeutic peptides, using insulin as drug model . The buccal permeability for peptides is rather low (0.1–5.0%) mainly due to high molecular weight and stability problems, which justifies the use of nanoparticles to enhance permeability [ 151 , 152 ].Author: Ana S. Macedo, Ana S. Macedo, Pedro M. Castro, Luís Roque, Natália G. Thomé, Catarina P. Reis, Manue...
https://www.researchgate.net/publication/230078371_Buccal_delivery_of_insulin_The_time_is_now
Buccal delivery of insulin: The time is now ... This has led to a battery of needle-free insulin delivery systems. Buccal delivery stands out as being safe, simple, fast, flexible, and familiar to ...Author: Gerald Bernstein
http://www.jpsbr.org/index_htm_files/11_JPSBR_12094.pdf
buccal delivery, which is drug administration through the mucosal membranes lining the cheeks (buccal mucosa).11-13 The present work is an effort to develop oral mucoadhesive delivery system for anti depressant drugs like fluoxetine hydrochloride. In this study, the drug was encapsulated into
https://link.springer.com/chapter/10.1007%2F978-1-4614-9524-6_19
Feb 04, 2014 · This delivery system is convenient for patients and can be self-administered using RapidMist™ technology. Insulin is sprayed via the RapidMist™ device into the mouth via an aerosolized spray. Tasteless mist of recombinant human insulin is thus administered to the buccal mucosa.Author: Meena Bansal, Sanjay Bansal, Rachna Kumria
https://link.springer.com/article/10.1007/s11095-007-9367-4
Jun 19, 2007 · To evaluate the pharmacological activity of insulin-loaded alginate/chitosan nanoparticles following oral dosage in diabetic rats. Nanoparticles were prepared by ionotropic pre-gelation of an alginate core followed by chitosan polyelectrolyte complexation. In vivo activity was evaluated by measuring the decrease in blood glucose concentrations in streptozotocin induced, …Author: B. Sarmento, A. Ribeiro, F. Veiga, P. Sampaio, R. Neufeld, D. Ferreira
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