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https://www.sciencedirect.com/science/article/pii/S1525001604015643
To understand better the structure/property relationships governing polymeric gene delivery, we synthesized polymers with 70 different primary structures, at 6 to 12 different molecular weights, using monomers previously identified as common to effective gene delivery polymers.Author: Daniel G. Anderson, Akin Akinc, Naushad Hossain, Robert Langer
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(04)01564-3
Mar 01, 2005 · To understand more completely the structure/function properties governing polymeric gene delivery, these polymers were (1) synthesized at a range of molecular weights, (2) tested in quadruplicate at six different polymer/DNA ratios, (3) complexed to DNA and (4) characterized for particle size and surface charge.Author: Daniel G. Anderson, Akin Akinc, Naushad Hossain, Robert Langer
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(04)01564-3.pdf
Structure/Property Studies of Polymeric Gene Delivery Using a Library of Poly(B-amino esters) Daniel G. Anderson, Akin Akinc, Naushad Hossain, and Robert Langer* Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA *To whom correspondence and reprint requests should be addressed. E-mail: [email protected].
https://www.researchgate.net/publication/8005567_Structureproperty_studies_of_polymeric_gene_delivery_using_a_library_of_poly-amino_esters
To understand better the structure/property relationships governing polymeric gene delivery, we synthesized polymers with 70 different primary structures, at 6 to 12 different molecular weights,...
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Based on the large number of studies of off-the-shelf and specifically designed gene delivery polymers, much has been learned about the structure-function relationships of polymer vectors. With growing understanding of polymer gene delivery mechanisms and continued efforts of creative and talented polymer chemists,...Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.researchgate.net/publication/230236927_Logical_Analysis_of_Data_in_Structure-Activity_Investigation_of_Polymeric_Gene_Delivery
Structure/property studies of polymeric gene delivery using a library of poly(-amino esters)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147627/
Jan 31, 2005 · PLL was one of the first polymers used in nonviral gene delivery, and a large variety of polymers with different molecular weights have been utilized in physicochemical and biological experiments . Due to its peptide structure, PLL is biodegradable, a property that makes it especially suitable for in vivo use; however the polymer exhibits modest to high toxicity.Author: H. Eliyahu, Y. Barenholz, A. J. Domb
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