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https://www.annualreviews.org/doi/10.1146/annurev.biophys.29.1.27
Owing to the rapid development of in vivo applications for non-viral gene delivery vectors, it is necessary to have a better understanding of how the structure-activity relationships of these lipid-DNA complexes are affected by their environment. Indeed, research in gene therapy first focused on in vitro cell culture studies to determine the mechanisms involved in the delivery of DNA into the ...Author: S. Chesnoy, L. Huang
https://www.annualreviews.org/doi/abs/10.1146/annurev.biophys.29.1.27
Owing to the rapid development of in vivo applications for non-viral gene delivery vectors, it is necessary to have a better understanding of how the structure-activity relationships of these lipid-DNA complexes are affected by their environment. Indeed, research in gene therapy first focused on in vitro cell culture studies to determine the mechanisms involved in the delivery of DNA into the ...Author: S. Chesnoy, L. Huang
https://www.researchgate.net/publication/12380992_Structure_and_Function_of_Lipid-DNA_Complexes_for_Gene_Delivery
Structure and Function of Lipid-DNA Complexes for Gene Delivery Article · Literature Review in Annual Review of Biophysics and Biomolecular Structure 29(1):27-47 · February 2000 with 40 Reads
https://www.ncbi.nlm.nih.gov/pubmed/10940242
Structure and function of lipid-DNA complexes for gene delivery. Chesnoy S(1), Huang L. Author information: (1)Department of Pharmacology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA. [email protected] Owing to the rapid development of in vivo applications for nonviral gene delivery vectors, it is necessary to have a ...Author: S. Chesnoy, L. Huang
https://www.sciencedirect.com/science/article/pii/S0959440X0000230X
The structure/function data obtained from the research should allow us to begin the formidable task of the rational design of these self assemblies for enhanced gene delivery applications from the ground up, beginning with the chemical structure of the lipids and the correct compositions of mixtures, including the functional plasmid.Author: Cyrus R Safinya
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1303908/
Cationic lipid-DNA (CL-DNA) complexes are abundantly used in nonviral gene therapy clinical applications. Surface functionality is the next step in developing these complexes as competent, target-specific gene carriers. Poly(ethylene glycol) (PEG) is ...Author: Ana Martin-Herranz, Ayesha Ahmad, Heather M. Evans, Kai Ewert, Uwe Schulze, Cyrus R. Safinya
https://www.sciencedirect.com/science/article/pii/S0006349504741909
Surface Functionalized Cationic Lipid-DNA Complexes for Gene Delivery: PEGylated Lamellar Complexes Exhibit Distinct DNA-DNA Interaction Regimes ... understanding the effects of incorporating PEG-lipids into CL-DNA complexes is crucial for the next step in gene delivery by CL-DNA complexes—adding target specificity with derivatives of PEG ...Author: Ana Martin-Herranz, Ayesha Ahmad, Heather M. Evans, Kai Ewert, Uwe Schulze, Cyrus R. Safinya
https://www.deepdyve.com/lp/elsevier/structures-of-lipid-dna-complexes-supramolecular-assembly-and-gene-oJOx90fB0l
Aug 01, 2001 · Read "Structures of lipid–DNA complexes: supramolecular assembly and gene delivery, Current Opinion in Structural Biology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.researchgate.net/publication/11848533_Structures_of_Lipid-DNA_Complexes_Supramolecular_Assembly_and_Gene_Delivery
Understanding the self-assembly of cationic lipids into liposomes or micelles, as well as studying the structure of their resulting complexes with DNA, is key to enhancing gene delivery research.Author: Cyrus R. Safinya
https://www.cell.com/biophysj/fulltext/S0006-3495(04)74190-9
Feb 01, 2004 · Cationic lipid-DNA (CL-DNA) complexes are abundantly used in nonviral gene therapy clinical applications. Surface functionality is the next step in developing these complexes as competent, target-specific gene carriers. Poly(ethylene glycol) (PEG) is the natural choice to serve as a protective coat or act as a tether for a specific ligand on the surface of these complexes due to its ...Author: Ana Martin-Herranz, Ayesha Ahmad, Heather M. Evans, Kai Ewert, Uwe Schulze, Cyrus R. Safinya
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