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https://www.tandfonline.com/doi/abs/10.1517/17425247.2011.554817
Areas covered: This review summarizes recent progress in the identification and validation of the target genes for cancer gene therapy using small interfering RNA (siRNA) technology and, more importantly, the delivery strategies that have been designed and implemented for tumor-directed delivery of siRNAs.Author: Ezharul Hoque Chowdhury
https://www.researchgate.net/publication/49829452_Strategies_for_tumor-directed_delivery_of_siRNA
Request PDF Strategies for tumor-directed delivery of siRNA Introduction: Current treatment of malignant tumors relies predominantly on chemotherapy delivering a single antineoplastic drug or ...Author: Ezharul Hoque Chowdhury
https://pubs.acs.org/doi/abs/10.1021/jacs.5b01435
A novel “collaborative assembly” approach was reported for the synthesis of an siRNA delivery system via a combination of an electrostatically driven physical assembly and a facile click reaction-mediated chemical assembly, which showed various advantages of more safety, efficiency, and flexibility over the conventional approach that is only based on the physical assembly.Author: Qiong Sun, Zisheng Kang, Lingjing Xue, Yunkai Shang, Zhigui Su, Hongbin Sun, Qineng Ping, Ran Mo, Ca...
https://pubs.acs.org/doi/10.1021/jacs.5b01435
A novel “collaborative assembly” approach was reported for the synthesis of an siRNA delivery system via a combination of an electrostatically driven physical assembly and a facile click reaction-mediated chemical assembly, which showed various advantages of more safety, efficiency, and flexibility over the conventional approach that is only based on the physical assembly.Author: Qiong Sun, Zisheng Kang, Lingjing Xue, Yunkai Shang, Zhigui Su, Hongbin Sun, Qineng Ping, Ran Mo, Ca...
https://www.sciencedirect.com/science/article/pii/S0169409X16301521
Though other delivery strategies are gaining attention, particularly including lipid-based siRNA delivery, many investigators continue to use and seek to improve polymeric nanoparticles, based on their stability, flexibility of modification, and high targetability.Author: So Jin Lee, So Jin Lee, Min Ju Kim, Min Ju Kim, Min Ju Kim, Ick Chan Kwon, Ick Chan Kwon, Thomas M. ...
https://www.sciencedirect.com/science/article/pii/S1742706116304251
To our knowledge, the described work is the first demonstration of a siRNA delivery system using a hypoxia trigger for regulation of siRNA release, which represents a new strategy for tumor-targeted therapy, and it is expected that this meaningful strategy must be widely applied in the future.Author: Lin Kang, Bo Fan, Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao
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